Use of genome-scale microbial models for metabolic engineering

Kiran Raosaheb Patil; M. Åkesson; Jens Nielsen

doi:10.1016/j.copbio.2003.11.003

Use of genome-scale microbial models for metabolic engineering

Kiran Raosaheb Patil
, M. Åkesson
, Jens Nielsen

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Metabolic engineering serves as an integrated approach to design new cell factories by providing rational design procedures and valuable mathematical and experimental tools. Mathematical models have an important role for phenotypic analysis, but can also be used for the design of optimal metabolic network structures. The major challenge for metabolic engineering in the post-genomic era is to broaden its design methodologies to incorporate genome-scale biological data. Genome-scale stoichiometric models of microorganisms represent a first step in this direction.

Original language	English
Journal	Current Opinion in Biotechnology
Volume	15
Issue number	1
Pages (from-to)	64-69
ISSN	0958-1669
DOIs	https://doi.org/10.1016/j.copbio.2003.11.003
Publication status	Published - 2004

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title = "Use of genome-scale microbial models for metabolic engineering",

abstract = "Metabolic engineering serves as an integrated approach to design new cell factories by providing rational design procedures and valuable mathematical and experimental tools. Mathematical models have an important role for phenotypic analysis, but can also be used for the design of optimal metabolic network structures. The major challenge for metabolic engineering in the post-genomic era is to broaden its design methodologies to incorporate genome-scale biological data. Genome-scale stoichiometric models of microorganisms represent a first step in this direction.",

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AU - Nielsen, Jens

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AB - Metabolic engineering serves as an integrated approach to design new cell factories by providing rational design procedures and valuable mathematical and experimental tools. Mathematical models have an important role for phenotypic analysis, but can also be used for the design of optimal metabolic network structures. The major challenge for metabolic engineering in the post-genomic era is to broaden its design methodologies to incorporate genome-scale biological data. Genome-scale stoichiometric models of microorganisms represent a first step in this direction.

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DO - 10.1016/j.copbio.2003.11.003

M3 - Journal article

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VL - 15

SP - 64

EP - 69

JO - Current Opinion in Biotechnology

JF - Current Opinion in Biotechnology

IS - 1

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Use of genome-scale microbial models for metabolic engineering

Abstract

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