Systems biology and biotechnology of Streptomyces species for the production of secondary metabolites

Research output: Contribution to journalJournal article – Annual report year: 2014Researchpeer-review

View graph of relations

Streptomyces species continue to attract attention as a source of novel medicinal compounds. Despite a long history of studies on these microorganisms, they still have many biochemical mysteries to be elucidated. Investigations of novel secondary metabolites and their biosynthetic gene clusters have been more systematized with high-throughput techniques through inspections of correlations among components of the primary and secondary metabolisms at the genome scale. Moreover, up-to-date information on the genome of Streptomyces species with emphasis on their secondary metabolism has been collected in the form of databases and knowledgebases, providing predictive information and enabling one to explore experimentally unrecognized biological spaces of secondary metabolism. Herein, we review recent trends in the systems biology and biotechnology of Streptomyces species.
Original languageEnglish
JournalBiotechnology Advances
Issue number2
Pages (from-to)255-268
Publication statusPublished - 2014
CitationsWeb of Science® Times Cited: No match on DOI

    Research areas

  • Streptomyces species, Secondary metabolites, Systems biology, Systems biotechnology, Systems metabolic engineering, Omics techniques, Databases, Knowledgebases, Constraint-based flux analysis
Download as:
Download as PDF
Select render style:
Download as HTML
Select render style:
Download as Word
Select render style:

ID: 89197148