Yeast-based screening platforms to understand and improve human health

Marcus Deichmann; Frederik G. Hansson; Emil D. Jensen

doi:10.1016/j.tibtech.2024.04.003

Yeast-based screening platforms to understand and improve human health

Marcus Deichmann, Frederik G. Hansson, Emil D. Jensen

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Detailed molecular understanding of the human organism is essential to develop effective therapies. Saccharomyces cerevisiae has been used extensively for acquiring insights into important aspects of human health, such as studying genetics and cell-cell communication, elucidating protein-protein interaction (PPI) networks, and investigating human G protein-coupled receptor (hGPCR) signaling. We highlight recent advances and opportunities of yeast-based technologies towards conducting cost-efficient chemical library screens on hGPCRs, accelerated deciphering of PPI networks with mating-based screening and selection, and for accurate cell-cell communication with human immune cells. Overall, yeast-based technologies constitute an important platform to support basic understanding and innovative applications towards improving human health..

Original language	English
Journal	Trends in Biotechnology
Volume	42
Issue number	10
Pages (from-to)	1258-1272
ISSN	0167-7799
DOIs	https://doi.org/10.1016/j.tibtech.2024.04.003
Publication status	Published - 2024

Keywords

G protein-coupled receptors
Cell-cell communication
Immune modulation
Protein-protein interaction networks
Yeast mating-based screening and selection
Yeast surface display

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tibtech.2024.04.003

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title = "Yeast-based screening platforms to understand and improve human health",

abstract = "Detailed molecular understanding of the human organism is essential to develop effective therapies. Saccharomyces cerevisiae has been used extensively for acquiring insights into important aspects of human health, such as studying genetics and cell-cell communication, elucidating protein-protein interaction (PPI) networks, and investigating human G protein-coupled receptor (hGPCR) signaling. We highlight recent advances and opportunities of yeast-based technologies towards conducting cost-efficient chemical library screens on hGPCRs, accelerated deciphering of PPI networks with mating-based screening and selection, and for accurate cell-cell communication with human immune cells. Overall, yeast-based technologies constitute an important platform to support basic understanding and innovative applications towards improving human health..",

keywords = "G protein-coupled receptors, Cell-cell communication, Immune modulation, Protein-protein interaction networks, Yeast mating-based screening and selection, Yeast surface display",

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doi = "10.1016/j.tibtech.2024.04.003",

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AU - Deichmann, Marcus

AU - Hansson, Frederik G.

AU - Jensen, Emil D.

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AB - Detailed molecular understanding of the human organism is essential to develop effective therapies. Saccharomyces cerevisiae has been used extensively for acquiring insights into important aspects of human health, such as studying genetics and cell-cell communication, elucidating protein-protein interaction (PPI) networks, and investigating human G protein-coupled receptor (hGPCR) signaling. We highlight recent advances and opportunities of yeast-based technologies towards conducting cost-efficient chemical library screens on hGPCRs, accelerated deciphering of PPI networks with mating-based screening and selection, and for accurate cell-cell communication with human immune cells. Overall, yeast-based technologies constitute an important platform to support basic understanding and innovative applications towards improving human health..

KW - G protein-coupled receptors

KW - Cell-cell communication

KW - Immune modulation

KW - Protein-protein interaction networks

KW - Yeast mating-based screening and selection

KW - Yeast surface display

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JO - Trends in Biotechnology

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ER -

Yeast-based screening platforms to understand and improve human health

Abstract

Keywords

UN SDGs

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