Wound degradomics – current status and future perspectives

Olivia Hermes, Pascal Schlage, Ulrich auf dem Keller

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Proteases are pivotal modulators of extracellular matrix components and bioactive proteins at all phases of cutaneous wound healing and thereby essentially contribute to the successful reestablishment of skin integrity upon injury. As a consequence, disturbance of proteolytic activity at the wound site is a major factor in the pathology of chronic wounds. A large body of data acquired in many years of research provide a good understanding of how individual proteases may influence the repair process. The next challenge will be to integrate these findings and to elucidate the complex interactions of proteolytic enzymes, their inhibitors and substrates on a system-wide level. Here, we present novel approaches that might help to achieve this ambitious goal in cutaneous wound healing research.
Original languageEnglish
JournalBiological Chemistry
Volume392
Issue number11
Pages (from-to)949-954
ISSN1431-6730
DOIs
Publication statusPublished - 2011
Externally publishedYes

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