Workshop on the validation and regulatory acceptance of innovative 3R approaches in regulatory toxicology - Evolution versus revolution

Research output: Contribution to journalJournal article – Annual report year: 2019Researchpeer-review

  • Author: Burgdorf, T.

    Federal Institute for Risk Assessment, Germany

  • Author: Piersma, Aldert H.

    Utrecht University, Netherlands

  • Author: Landsiedel, Robert

    BASF, Germany

  • Author: Clewell, R

    21st Century Tox Consulting, United States

  • Author: Kleinstreuer, N

    National Institute of Environmental Health Sciences Research, United States

  • Author: Oelgeschläger, M.

    Federal Institute for Risk Assessment, Germany

  • Author: Desprez, B.

    Cosmetics Europe – The Personal Care Association, Netherlands

  • Author: Kienhuis, A.

    National Institute for Public Health and the Environment, Netherlands

  • Author: Bos, P.

    National Institute for Public Health and the Environment, Netherlands

  • Author: de Vries, R.P.

    Johns Hopkins Bloomberg School of Public Health, Netherlands

  • Author: de Wit, L

    National Institute for Public Health and the Environment, Netherlands

  • Author: Seidle, T

    Humane Society International, Canada

  • Author: Scheel, Jesper

    Department of Health Technology, Technical University of Denmark, Ørsteds Plads, 2800, Kgs. Lyngby, Denmark

  • Author: Schoenfelder, Gilbert

    Evonik Performance Materials GmbH, Germany

  • Author: van Benthem, Koen J.

    National Institute for Public Health and the Environment, Netherlands

  • Author: Vinggaard, Anne Marie

    Copenhagen Center for Health Technology, Centers, Research group for Molecular and Reproductive Toxicology, National Food Institute, Technical University of Denmark, Kemitorvet, 2800, Kgs. Lyngby, Denmark

  • Author: Eskes, C.

    Swiss 3R Competence Centre, Switzerland

  • Author: Ezendam, Janine

    National Institute for Public Health and the Environment, Netherlands

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At a joint workshop organized by RIVM and BfR, international experts from governmental institutes, regulatory agencies, industry, academia and animal welfare organizations discussed and provided recommendations for the development, validation and implementation of innovative 3R approaches in regulatory toxicology. In particular, an evolutionary improvement of our current approach of test method validation in the context of defined approaches or integrated testing strategies was discussed together with a revolutionary approach based on a comprehensive description of the physiological responses of the human body to chemical exposure and the subsequent definition of relevant and predictive in vitro, in chemico or in silico methods. A more comprehensive evaluation of biological relevance, scientific validity and regulatory purpose of new test methods and assessment strategies together with case studies that provide practical experience with new approaches were discussed as essential steps to build up the necessary confidence to facilitate regulatory acceptance.
Original languageEnglish
JournalToxicology in Vitro
Volume59
Pages (from-to)1-11
ISSN0887-2333
DOIs
Publication statusPublished - 2019
CitationsWeb of Science® Times Cited: No match on DOI

    Research areas

  • Case studies, Evolution, Relevance, Revolution, Validation, Workshop

ID: 173173274