Within-host evolution of Pseudomonas aeruginosa toward iron acquisition from hemoglobin in polymicrobial CF infections

Seyed Mohammad Hossein Khademi, Rasmus Lykke Marvig, Søren Damkiær Pedersen, Lars Jelsbak

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    Abstract

    Bacterial pathogens require iron to survive and colonize a human host but their access to free iron is often limited by iron-withholding process where free iron is bound by proteins such as hemoglobin. Although most pathogens have developed tactics to acquire iron from host proteins, little is known about how evolutionary
    processes modulate bacterial iron acquisition systems in chronic, polymicrobial
    infections where interspecies competition for limited iron could be an
    evolutionary driver.
    Original languageEnglish
    Title of host publicationProceedings of the 5th ASM Conference on Cell-Cell Communication in Bacteria
    PublisherAmerican Society for Microbiology
    Publication date2014
    Pages60-61
    Article number46
    Publication statusPublished - 2014
    Event5th ASM Conference on Cell-Cell Communication in Bacteria - San Antonio, Texas, United States
    Duration: 18 Oct 201421 Oct 2014
    Conference number: 5
    http://conferences.asm.org/index.php/2012-02-09-21-04-52/past-conferences/9-past-conferences/172-5th-asm-conference-on-cell-cell-communication-in-bacteria

    Conference

    Conference5th ASM Conference on Cell-Cell Communication in Bacteria
    Number5
    CountryUnited States
    CitySan Antonio, Texas
    Period18/10/201421/10/2014
    Internet address

    Cite this

    Khademi, S. M. H., Marvig, R. L., Pedersen, S. D., & Jelsbak, L. (2014). Within-host evolution of Pseudomonas aeruginosa toward iron acquisition from hemoglobin in polymicrobial CF infections. In Proceedings of the 5th ASM Conference on Cell-Cell Communication in Bacteria (pp. 60-61). [46] American Society for Microbiology.