Wireless Direct Microampere Current in Wound Healing: Clinical and Immunohistological Data from Two Single Case Reports

Research output: Contribution to journalJournal article – Annual report year: 2019Researchpeer-review



  • Author: Lagoumintzis, George

    University of Patras, Greece

  • Author: Zagoriti, Zoi

    University of Patras, Greece

  • Author: Jensen, Mogens S.

    Department of Physics, Technical University of Denmark, Fysikvej, 2800, Kgs. Lyngby, Denmark

  • Author: Argyrakos, Theodoros

    Evaggelismos General Hospital, Greece

  • Author: Koutsojannis, Constantinos

    University of Patras, Greece

  • Author: Poulas, Konstantinos

    University of Patras, Greece

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Chronic pressure ulcers are hard-to-heal wounds that decrease the patient's quality of life. Wireless Micro Current Stimulation (WMCS) is an innovative, non-invasive, similar to electrode-based electrostimulation (ES) technology, that generates and transfers ions that are negatively-charged to the injured tissue, using accessible air gases as a transfer medium. WMCS is capable of generating similar tissue potentials, as electrode-based ES, for injured tissue. Here, through immunohistochemistry, we intended to characterize the induced tissue healing biological mechanisms that occur during WMCS therapy. Two single cases of bedridden due to serious stroke white men with chronic non-healing pressure ulcers have been treated with WMCS technology. WMCS suppresses inflammatory responses by decreasing the aggregation of granulocytes, followed by stimulating myofibroblastic activity and a new formation of collagen fibers, as depicted by immunohistochemistry. As a result, WMCS provides a special adjunct or stand-alone therapy choice for chronic and non-healing injuries, similar to electrode-based ES, but with added (i.e., contactless) benefits towards its establishment as a routine clinical wound healing regime.
Original languageEnglish
Article number107
Issue number3
Number of pages12
Publication statusPublished - 2019
CitationsWeb of Science® Times Cited: No match on DOI

    Research areas

  • Chronic wounds, Electrical stimulation, Direct microcurrent, Nin-invasive, Pressure ulcer, Wireless technology

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ID: 192322916