Whole organ and tissue reconstruction in thoracic regenerative surgery

Mei Ling Lim, Philipp Jungebluth, Fatemeh Ajalloueian, Linda Helen Friedrich, Irina Gilevich, Karl Henrik Grinnemo, Elena Gubareva, Johannes C. Haag, Greg Lemon, Sebastian Sjöqvist, Arthur L. Caplan, Paolo Macchiarini*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review


Development of novel prognostic, diagnostic, and treatment options will provide major benefits for millions of patients with acute or chronic respiratory dysfunction, cardiac-related disorders, esophageal problems, or other diseases in the thorax. Allogeneic organ transplant is currently available. However, it remains a trap because of its dependency on a very limited supply of donated organs, which may be needed for both initial and subsequent transplants. Furthermore, it requires lifelong treatment with immunosuppressants, which are associated with adverse effects. Despite early clinical applications of bioengineered organs and tissues, routine implementation is still far off. For this review, we searched the PubMed, MEDLINE, and Ovid databases for the following keywords for each tissue or organ: tissue engineering, biological and synthetic scaffold/graft, acellular and decelluar(ized), reseeding, bioreactor, tissue replacement, and transplantation. We identified the current state-of-the-art practices in tissue engineering with a focus on advances during the past 5 years. We discuss advantages and disadvantages of biological and synthetic solutions and introduce novel strategies and technologies for the field. The ethical challenges of innovation in this area are also reviewed.

Original languageEnglish
JournalMayo Clinic Proceedings
Issue number10
Pages (from-to)1151-1166
Number of pages16
Publication statusPublished - 2013
Externally publishedYes


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