Whole genome sequencing for childhood cancer in Denmark

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    The talk will describe our involvement in the Danish project STAGING, “Sequencing Three Actionable Genomes – Implications & National Guidelines”, an interdisciplinary, multi-tiered 3-year study of 600 consecutive childhood cancer patients and their families, with extensive genomic sequencing of host, tumour and gut microbiome’s genomes. In Europe, cancer accounts for approximately 25% of all deaths in children >1 year. Most cured patients are burdened by late effects, including risk of second cancer and debilitating toxicities. Recent advancements in genetic sequencing technology and reduction in costs have led to new strategies for identification of cancer predisposition and targeted treatment. STAGING is a nation-wide programme offering full, up-front genetic testing for childhood cancer patients and implements the findings into health care. Paediatric oncology provides a unique proof- of-principle framework for such a program, since it is one of the best organized medical specialties with nation-wide strategies for diagnostics, therapy, deep response phenotyping, and follow-up.
    Original languageEnglish
    Publication date2016
    Number of pages1
    Publication statusPublished - 2016
    EventSustain-ATV Conference 2016: Creating Technology for a Sustainable Society - Technical University of Denmark, Kgs. Lyngby, Denmark
    Duration: 30 Nov 201630 Nov 2016


    ConferenceSustain-ATV Conference 2016
    LocationTechnical University of Denmark
    CityKgs. Lyngby
    Internet address

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