WHO global research priorities for antimicrobial resistance in human health

Silvia Bertagnolio; Zlatina Dobreva; Chad M. Centner; Ioana Diana Olaru; Daniele Donà; Stefano Burzo; Benedikt D. Huttner; Antoine Chaillon; Nebiat Gebreselassie; Teodora Wi; Mateusz Hasso-Agopsowicz; Benedetta Allegranzi; Hatim Sati; Verica Ivanovska; Kavita U. Kothari; Hanan H. Balkhy; Alessandro Cassini; Raph L. Hamers; Kitty Van Weezenbeek; WHO Research Agenda for AMR in Human Health Collaborators

doi:10.1016/S2666-5247(24)00134-4

WHO global research priorities for antimicrobial resistance in human health

Silvia Bertagnolio^*, Zlatina Dobreva, Chad M. Centner, Ioana Diana Olaru, Daniele Donà, Stefano Burzo, Benedikt D. Huttner, Antoine Chaillon, Nebiat Gebreselassie, Teodora Wi, Mateusz Hasso-Agopsowicz, Benedetta Allegranzi, Hatim Sati, Verica Ivanovska, Kavita U. Kothari, Hanan H. Balkhy, Alessandro Cassini, Raph L. Hamers, Kitty Van Weezenbeek, WHO Research Agenda for AMR in Human Health Collaborators

^*Corresponding author for this work

Research output: Contribution to journal › Review › peer-review

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Abstract

The WHO research agenda for antimicrobial resistance (AMR) in human health has identified 40 research priorities to be addressed by the year 2030. These priorities focus on bacterial and fungal pathogens of crucial importance in addressing AMR, including drug-resistant pathogens causing tuberculosis. These research priorities encompass the entire people-centred journey, covering prevention, diagnosis, and treatment of antimicrobial-resistant infections, in addition to addressing the overarching knowledge gaps in AMR epidemiology, burden and drivers, policies and regulations, and awareness and education. The research priorities were identified through a multistage process, starting with a comprehensive scoping review of knowledge gaps, with expert inputs gathered through a survey and open call. The priority setting involved a rigorous modified Child Health and Nutrition Research Initiative approach, ensuring global representation and applicability of the findings. The ultimate goal of this research agenda is to encourage research and investment in the generation of evidence to better understand AMR dynamics and facilitate policy translation for reducing the burden and consequences of AMR.

Original language	English
Article number	100902
Journal	The Lancet Microbe
ISSN	2666-5247
DOIs	https://doi.org/10.1016/S2666-5247(24)00134-4
Publication status	Accepted/In press - 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Bertagnolio, S., Dobreva, Z., Centner, C. M., Olaru, I. D., Donà, D., Burzo, S., Huttner, B. D., Chaillon, A., Gebreselassie, N., Wi, T., Hasso-Agopsowicz, M., Allegranzi, B., Sati, H., Ivanovska, V., Kothari, K. U., Balkhy, H. H., Cassini, A., Hamers, R. L., Weezenbeek, K. V., & WHO Research Agenda for AMR in Human Health Collaborators (Accepted/In press). WHO global research priorities for antimicrobial resistance in human health. The Lancet Microbe, Article 100902. https://doi.org/10.1016/S2666-5247(24)00134-4

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abstract = "The WHO research agenda for antimicrobial resistance (AMR) in human health has identified 40 research priorities to be addressed by the year 2030. These priorities focus on bacterial and fungal pathogens of crucial importance in addressing AMR, including drug-resistant pathogens causing tuberculosis. These research priorities encompass the entire people-centred journey, covering prevention, diagnosis, and treatment of antimicrobial-resistant infections, in addition to addressing the overarching knowledge gaps in AMR epidemiology, burden and drivers, policies and regulations, and awareness and education. The research priorities were identified through a multistage process, starting with a comprehensive scoping review of knowledge gaps, with expert inputs gathered through a survey and open call. The priority setting involved a rigorous modified Child Health and Nutrition Research Initiative approach, ensuring global representation and applicability of the findings. The ultimate goal of this research agenda is to encourage research and investment in the generation of evidence to better understand AMR dynamics and facilitate policy translation for reducing the burden and consequences of AMR.",

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note = "Publisher Copyright: {\textcopyright} 2024",

year = "2024",

doi = "10.1016/S2666-5247(24)00134-4",

language = "English",

journal = "The Lancet Microbe",

issn = "2666-5247",

publisher = "Elsevier",

}

Bertagnolio, S, Dobreva, Z, Centner, CM, Olaru, ID, Donà, D, Burzo, S, Huttner, BD, Chaillon, A, Gebreselassie, N, Wi, T, Hasso-Agopsowicz, M, Allegranzi, B, Sati, H, Ivanovska, V, Kothari, KU, Balkhy, HH, Cassini, A, Hamers, RL, Weezenbeek, KV & WHO Research Agenda for AMR in Human Health Collaborators 2024, 'WHO global research priorities for antimicrobial resistance in human health', The Lancet Microbe. https://doi.org/10.1016/S2666-5247(24)00134-4

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T1 - WHO global research priorities for antimicrobial resistance in human health

AU - Bertagnolio, Silvia

AU - Dobreva, Zlatina

AU - Centner, Chad M.

AU - Olaru, Ioana Diana

AU - Donà, Daniele

AU - Burzo, Stefano

AU - Huttner, Benedikt D.

AU - Chaillon, Antoine

AU - Gebreselassie, Nebiat

AU - Wi, Teodora

AU - Hasso-Agopsowicz, Mateusz

AU - Allegranzi, Benedetta

AU - Sati, Hatim

AU - Ivanovska, Verica

AU - Kothari, Kavita U.

AU - Balkhy, Hanan H.

AU - Cassini, Alessandro

AU - Hamers, Raph L.

AU - Weezenbeek, Kitty Van

AU - WHO Research Agenda for AMR in Human Health Collaborators

A2 - Aanensen, David

A2 - Alanio, Alexandre

A2 - Alastruey-Izquierdo, Ana

A2 - Alemayehu, Tinsae

A2 - Al-Hasan, Majdi

A2 - Allegaert, Karel

A2 - Al-Maani, Amal Saif

A2 - Al-Salman, Jameela

A2 - Alshukairi, Abeer Nizar

A2 - Amir, Afreenish

A2 - Applegate, Tanya

A2 - Araj, George F.

A2 - Villalobos, Marlen Arce

A2 - Årdal, Christine

A2 - Ashiru-Oredope, Diane

A2 - Ashley, Elizabeth A.

A2 - Babin, François Xavier

A2 - Bachmann, Laura H.

A2 - Bachmann, Till

A2 - Baker, Kate Susan

A2 - Balasegaram, Manica

A2 - Bamford, Colleen

A2 - Baquero, Fernando

A2 - Barcelona, Laura Isabel

A2 - Bassat, Quique

A2 - Bassetti, Matteo

A2 - Basu, Sulagna

A2 - Beardsley, Justin

A2 - Vásquez, Grey Benoit

A2 - Berkley, James A.

A2 - Bhatnagar, Anuj K.

A2 - Bielicki, Julia

A2 - Bines, Julie

A2 - Bongomin, Felix

A2 - Bonomo, Robert A.

A2 - Bradley, John S.

A2 - Bradshaw, Catriona

A2 - Brett, Ana

A2 - Brink, Adrian

A2 - Brown, Colin

A2 - Brown, Jeremy

A2 - Buising, Kirsty

A2 - Carson, Carolee

A2 - Carvalho, Anna Cristina

A2 - Castagnola, Elio

A2 - Cavaleri, Marco

A2 - Cecchini, Michele

A2 - Chabala, Chishala

A2 - Chaisson, Richard E.

A2 - Chakrabarti, Arunaloke

A2 - Chandler, Clare

A2 - Chandy, Sujith John

A2 - Charani, Esmita

A2 - Chen, Lisa

A2 - Chiara, Francesca

A2 - Chowdhary, Anuradha

A2 - Chua, Arlene

A2 - Chuki, Pem

A2 - Chun, Doo Ryeon

A2 - Churchyard, Gavin

A2 - Cirillo, Daniela

A2 - Clack, Lauren

A2 - Coffin, Susan E.

A2 - Cohn, Jennifer

A2 - Cole, Michelle

A2 - Conly, John

A2 - Cooper, Ben

A2 - Corso, Alejandra

A2 - Cosgrove, Sara E.

A2 - Cox, Helen

A2 - Daley, Charles L.

A2 - Darboe, Saffiatou

A2 - Darton, Tom

A2 - Davies, Gerry

A2 - de Egea, Viviana

A2 - Dedeić-Ljubović, Amela

A2 - Deeves, Miranda

A2 - Denkinger, Claudia

A2 - Dillon, Jo-Anne R.

A2 - Dramowski, Angela

A2 - Eley, Brian

A2 - Esposito, Susanna Maria Roberta

A2 - Essack, Sabiha Y.

A2 - Farida, Helmia

A2 - Farooqi, Joveria

A2 - Feasey, Nicholas

A2 - Ferreyra, Cecilia

A2 - Fifer, Helen

A2 - Finlayson, Heather

A2 - Frick, Mike

A2 - Gales, Ana Cristina

A2 - Galli, Luisa

A2 - Gandra, Sumanth

A2 - Gerber, Jeffrey S.

A2 - Giske, Christian

A2 - Gordon, Bruce

A2 - Govender, Nelesh

A2 - Guessennd, Nathalie

A2 - Guindo, Ibrehima

A2 - Gurbanova, Elmira

A2 - Gwee, Amanda

A2 - Hagen, Ferry

A2 - Harbarth, Stephan

A2 - Haze, John

A2 - Heim, Jutta

A2 - Hendriksen, Rene

A2 - Heyderman, Robert Simon

A2 - Holt, Kathryn Elizabeth

A2 - Hönigl, Martin

A2 - Hook, Edward W.

A2 - Hope, William

A2 - Hopkins, Heidi

A2 - Hughes, Gwenda

A2 - Ismail, Ghada

A2 - Issack, Mohammad Iqbal

A2 - Jacobs, Jan

A2 - Jasovský, Dušan

A2 - Jehan, Fyeza

A2 - Pearson, Antonieta Jimenez

A2 - Jones, Makoto

A2 - Joshi, Mohan P.

A2 - Kapil, Arti

A2 - Kariuki, Samuel

A2 - Karkey, Abhilasha

A2 - Kearns, Gregory L.

A2 - Keddy, Karen Helena

A2 - Khanna, Nina

A2 - Kitamura, Akiko

A2 - Kolho, Kaija-Leena

A2 - Kontoyiannis, Dimitrios P.

A2 - Kotwani, Anita

A2 - Kozlov, Roman S.

A2 - Kranzer, Katharina

A2 - Kularatne, Ranmini

A2 - Lahra, Monica M.

A2 - Langford, Bradley J.

A2 - Laniado-Laborin, Rafael

A2 - Larsson, Joakim

A2 - Lass-Flörl, Cornelia

A2 - Le Doare, Kirsty

A2 - Lee, Hyukmin

A2 - Lessa, Fernanda

A2 - Levin, Anna S.

A2 - Limmathurotsakul, Direk

A2 - Lincopan, Nilton

A2 - Lo Vecchio, Andrea

A2 - Lodha, Rakesh

A2 - Loeb, Mark

A2 - Longtin, Yves

A2 - Lye, David Chien

A2 - Mahmud, Asif Mujtaba

A2 - Manaia, Célia

A2 - Manderson, Lenore

A2 - Mareković, Ivana

A2 - Marimuthu, Kalisvar

A2 - Martin, Irene

A2 - Mashe, Tapfumanei

A2 - Mei, Zeng

A2 - Meis, Jacques F.

A2 - De Melo, Flávio Augusto Lyra Tavares

A2 - Mendelson, Marc

A2 - Miranda, Angelica Espinosa

A2 - Moore, David

A2 - Morel, Chantal

A2 - Moremi, Nyambura

A2 - Moro, Maria Luisa

A2 - Moussy, Francis

A2 - Mshana, Stephen

A2 - Mueller, Arno

A2 - Ndow, Francis J.

A2 - Nicol, Mark

A2 - Nunn, Andrew

A2 - Obaro, Stephen

A2 - Obiero, Christina W.

A2 - Okeke, Iruka N.

A2 - Okomo, Uduak

A2 - Okwor, Tochi J.

A2 - Oladele, Rita

A2 - Omulo, Sylvia

A2 - Ondoa, Pascale

A2 - de Canese, Juana Medarda Ortellado

A2 - Ostrosky-Zeichner, Luis

A2 - Padoveze, Maria Clara

A2 - Pai, Madhukar

A2 - Park, Benjamin

A2 - Parkhill, Julian

A2 - Parry, Christopher M.

A2 - Peeling, Rosanna

A2 - Peixe, Luísa Maria Sobreira Vieira

A2 - Perovic, Olga

A2 - Pettigrew, Melinda M.

A2 - Principi, Nicola

A2 - Pulcini, Céline

A2 - Puspandari, Nelly

A2 - Rawson, Timothy

A2 - Reddy, Denasha Lavanya

A2 - Reddy, Kessendri

A2 - Redner, Paulo

A2 - Tudela, Juan Luis Rodríguez

A2 - Rodríguez-Baño, Jesús

A2 - Van Katwyk, Susan Rogers

A2 - Roilides, Emmanuel

A2 - Rollier, Christine

A2 - Rollock, Leslie

A2 - Ronat, Jean-Baptiste

A2 - Ruppe, Etienne

A2 - Sadarangani, Manish

A2 - Salisbury, David

A2 - Salou, Mounerou

A2 - Samison, Luc Hervé

A2 - Sanguinetti, Maurizio

A2 - Sartelli, Massimo

A2 - Schellack, Natalie

A2 - Schouten, Jeroen

A2 - Schwaber, Mitchell J.

A2 - Seni, Jeremiah

A2 - Senok, Abiola

A2 - Shafer, William M.

A2 - Shakoor, Sadia

A2 - Sheppard, Donald

A2 - Shin, Jong-Hee

A2 - Sia, Sonia

A2 - Sievert, Dawn

A2 - Singh, Ishwar

A2 - Singla, Rupak

A2 - Skov, Robert Leo

A2 - Soge, Olusegun O.

A2 - Sprute, Rosanne

A2 - Srinivasan, Arjun

A2 - Srinivasan, Subasree

A2 - Sundsfjord, Arnfinn

A2 - Tacconelli, Evelina

A2 - Tahseen, Sabira

A2 - Tangcharoensathien, Viroj

A2 - Tängdén, Thomas

A2 - Thursky, Karin

A2 - Thwaites, Guy

A2 - Peral, Renata Tigulini de Souza

A2 - Tong, Deborah

A2 - Tootla, Hafsah Deepa

A2 - Tsioutis, Constantinos

A2 - Turner, Katy M.

A2 - Turner, Paul

A2 - Omar, Shaheed Vally

A2 - van de Sande, Wendy W.J.

A2 - van den Hof, Susan

A2 - van Doorn, Rogier

A2 - Veeraraghavan, Balaji

A2 - Verweij, Paul

A2 - Wahyuningsih, Retno

A2 - Wang, Hui

A2 - Warris, Adilia

A2 - Weinstock, Hillard

A2 - Wesangula, Evelyn

A2 - Whiley, David

A2 - White, Peter J.

A2 - Williams, Phoebe

A2 - Xiao, Yonghong

A2 - Moscoso, Martin Yagui

A2 - Yang, Hsu Li

A2 - Yoshida, Sachiyo

A2 - Yu, Yunsong

A2 - Żabicka, Dorota

A2 - Zignol, Matteo

A2 - Rudan, Igor

PY - 2024

Y1 - 2024

N2 - The WHO research agenda for antimicrobial resistance (AMR) in human health has identified 40 research priorities to be addressed by the year 2030. These priorities focus on bacterial and fungal pathogens of crucial importance in addressing AMR, including drug-resistant pathogens causing tuberculosis. These research priorities encompass the entire people-centred journey, covering prevention, diagnosis, and treatment of antimicrobial-resistant infections, in addition to addressing the overarching knowledge gaps in AMR epidemiology, burden and drivers, policies and regulations, and awareness and education. The research priorities were identified through a multistage process, starting with a comprehensive scoping review of knowledge gaps, with expert inputs gathered through a survey and open call. The priority setting involved a rigorous modified Child Health and Nutrition Research Initiative approach, ensuring global representation and applicability of the findings. The ultimate goal of this research agenda is to encourage research and investment in the generation of evidence to better understand AMR dynamics and facilitate policy translation for reducing the burden and consequences of AMR.

AB - The WHO research agenda for antimicrobial resistance (AMR) in human health has identified 40 research priorities to be addressed by the year 2030. These priorities focus on bacterial and fungal pathogens of crucial importance in addressing AMR, including drug-resistant pathogens causing tuberculosis. These research priorities encompass the entire people-centred journey, covering prevention, diagnosis, and treatment of antimicrobial-resistant infections, in addition to addressing the overarching knowledge gaps in AMR epidemiology, burden and drivers, policies and regulations, and awareness and education. The research priorities were identified through a multistage process, starting with a comprehensive scoping review of knowledge gaps, with expert inputs gathered through a survey and open call. The priority setting involved a rigorous modified Child Health and Nutrition Research Initiative approach, ensuring global representation and applicability of the findings. The ultimate goal of this research agenda is to encourage research and investment in the generation of evidence to better understand AMR dynamics and facilitate policy translation for reducing the burden and consequences of AMR.

U2 - 10.1016/S2666-5247(24)00134-4

DO - 10.1016/S2666-5247(24)00134-4

M3 - Review

AN - SCOPUS:85201120507

SN - 2666-5247

JO - The Lancet Microbe

JF - The Lancet Microbe

M1 - 100902

ER -

WHO global research priorities for antimicrobial resistance in human health

Abstract

UN SDGs

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