White matter changes contribute to corpus callosum atrophy in the elderly: The LADIS study

C. Ryberg; E. Rostrup; Karl Sjöstrand; O. B. Paulson; F. Barkhof; P. Scheltens; E. C. W. van Straaten; F. Fazekas; R. Schmidt; T. Erkinjuntti; L. -O. Wahlund; A. M. Basile; L. Pantoni; D. Inzitari; G. Waldemar

doi:10.3174/ajnr.A1169

White matter changes contribute to corpus callosum atrophy in the elderly: The LADIS study

C. Ryberg, E. Rostrup, Karl Sjöstrand, O. B. Paulson, F. Barkhof, P. Scheltens, E. C. W. van Straaten, F. Fazekas, R. Schmidt, T. Erkinjuntti, L. -O. Wahlund, A. M. Basile, L. Pantoni, D. Inzitari, G. Waldemar

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Abstract

BACKGROUND AND PURPOSE: The corpus callosum (CC) is the most important structure involved in the transmission of interhemispheric information. The aim of this study was to investigate the potential correlation between regional age-related white matter changes (ARWMC) and atrophy of CC in elderly subjects.MATERIALS AND METHODS: In 578 subjects with ARWMC from the Leukoaraiosis And DISability (LADIS) study, the cross-sectional area of the CC was automatically segmented on the normalized midsagittal MR imaging section and subdivided into 5 regions The ARWMC volumes were measured quantitatively by using a semiautomated technique and segmented into 6 brain regions.RESULTS: Significant correlation between the area of the rostrum and splenium regions of the CC and the ARWMC load in most brain regions was identified. This correlation persisted after correction for global atrophy.CONCLUSION: Increasing loads of ARWMC volume were significantly correlated with atrophy of the CC and its subregions in nondisabled elderly subjects with leukoaraiosis. However, the pattern of correlation between CC subregions and ARWMC was not specifically related to the topographic location of ARWMC. The results suggest that ARWMC may lead to a gradual loss of CC tissue.

Original language	English
Journal	American Journal of Neuroradiology
Volume	29
Issue number	8
Pages (from-to)	1498-1504
ISSN	0195-6108
DOIs	https://doi.org/10.3174/ajnr.A1169
Publication status	Published - 2008

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Ryberg, C., Rostrup, E., Sjöstrand, K., Paulson, O. B., Barkhof, F., Scheltens, P., van Straaten, E. C. W., Fazekas, F., Schmidt, R., Erkinjuntti, T., Wahlund, L. .-O., Basile, A. M., Pantoni, L., Inzitari, D., & Waldemar, G. (2008). White matter changes contribute to corpus callosum atrophy in the elderly: The LADIS study. American Journal of Neuroradiology, 29(8), 1498-1504. https://doi.org/10.3174/ajnr.A1169

@article{cca599a7b0364c4f90c26284a7a93d93,

title = "White matter changes contribute to corpus callosum atrophy in the elderly: The LADIS study",

abstract = "BACKGROUND AND PURPOSE: The corpus callosum (CC) is the most important structure involved in the transmission of interhemispheric information. The aim of this study was to investigate the potential correlation between regional age-related white matter changes (ARWMC) and atrophy of CC in elderly subjects.MATERIALS AND METHODS: In 578 subjects with ARWMC from the Leukoaraiosis And DISability (LADIS) study, the cross-sectional area of the CC was automatically segmented on the normalized midsagittal MR imaging section and subdivided into 5 regions The ARWMC volumes were measured quantitatively by using a semiautomated technique and segmented into 6 brain regions.RESULTS: Significant correlation between the area of the rostrum and splenium regions of the CC and the ARWMC load in most brain regions was identified. This correlation persisted after correction for global atrophy.CONCLUSION: Increasing loads of ARWMC volume were significantly correlated with atrophy of the CC and its subregions in nondisabled elderly subjects with leukoaraiosis. However, the pattern of correlation between CC subregions and ARWMC was not specifically related to the topographic location of ARWMC. The results suggest that ARWMC may lead to a gradual loss of CC tissue.",

author = "C. Ryberg and E. Rostrup and Karl Sj{\"o}strand and Paulson, {O. B.} and F. Barkhof and P. Scheltens and {van Straaten}, {E. C. W.} and F. Fazekas and R. Schmidt and T. Erkinjuntti and Wahlund, {L. -O.} and Basile, {A. M.} and L. Pantoni and D. Inzitari and G. Waldemar",

year = "2008",

doi = "10.3174/ajnr.A1169",

language = "English",

volume = "29",

pages = "1498--1504",

journal = "American Journal of Neuroradiology",

issn = "0195-6108",

publisher = "American Society of Neuroradiology",

number = "8",

}

Ryberg, C, Rostrup, E, Sjöstrand, K, Paulson, OB, Barkhof, F, Scheltens, P, van Straaten, ECW, Fazekas, F, Schmidt, R, Erkinjuntti, T, Wahlund, L-O, Basile, AM, Pantoni, L, Inzitari, D & Waldemar, G 2008, 'White matter changes contribute to corpus callosum atrophy in the elderly: The LADIS study', American Journal of Neuroradiology, vol. 29, no. 8, pp. 1498-1504. https://doi.org/10.3174/ajnr.A1169

TY - JOUR

T1 - White matter changes contribute to corpus callosum atrophy in the elderly: The LADIS study

AU - Ryberg, C.

AU - Rostrup, E.

AU - Sjöstrand, Karl

AU - Paulson, O. B.

AU - Barkhof, F.

AU - Scheltens, P.

AU - van Straaten, E. C. W.

AU - Fazekas, F.

AU - Schmidt, R.

AU - Erkinjuntti, T.

AU - Wahlund, L. -O.

AU - Basile, A. M.

AU - Pantoni, L.

AU - Inzitari, D.

AU - Waldemar, G.

PY - 2008

Y1 - 2008

N2 - BACKGROUND AND PURPOSE: The corpus callosum (CC) is the most important structure involved in the transmission of interhemispheric information. The aim of this study was to investigate the potential correlation between regional age-related white matter changes (ARWMC) and atrophy of CC in elderly subjects.MATERIALS AND METHODS: In 578 subjects with ARWMC from the Leukoaraiosis And DISability (LADIS) study, the cross-sectional area of the CC was automatically segmented on the normalized midsagittal MR imaging section and subdivided into 5 regions The ARWMC volumes were measured quantitatively by using a semiautomated technique and segmented into 6 brain regions.RESULTS: Significant correlation between the area of the rostrum and splenium regions of the CC and the ARWMC load in most brain regions was identified. This correlation persisted after correction for global atrophy.CONCLUSION: Increasing loads of ARWMC volume were significantly correlated with atrophy of the CC and its subregions in nondisabled elderly subjects with leukoaraiosis. However, the pattern of correlation between CC subregions and ARWMC was not specifically related to the topographic location of ARWMC. The results suggest that ARWMC may lead to a gradual loss of CC tissue.

AB - BACKGROUND AND PURPOSE: The corpus callosum (CC) is the most important structure involved in the transmission of interhemispheric information. The aim of this study was to investigate the potential correlation between regional age-related white matter changes (ARWMC) and atrophy of CC in elderly subjects.MATERIALS AND METHODS: In 578 subjects with ARWMC from the Leukoaraiosis And DISability (LADIS) study, the cross-sectional area of the CC was automatically segmented on the normalized midsagittal MR imaging section and subdivided into 5 regions The ARWMC volumes were measured quantitatively by using a semiautomated technique and segmented into 6 brain regions.RESULTS: Significant correlation between the area of the rostrum and splenium regions of the CC and the ARWMC load in most brain regions was identified. This correlation persisted after correction for global atrophy.CONCLUSION: Increasing loads of ARWMC volume were significantly correlated with atrophy of the CC and its subregions in nondisabled elderly subjects with leukoaraiosis. However, the pattern of correlation between CC subregions and ARWMC was not specifically related to the topographic location of ARWMC. The results suggest that ARWMC may lead to a gradual loss of CC tissue.

U2 - 10.3174/ajnr.A1169

DO - 10.3174/ajnr.A1169

M3 - Journal article

C2 - 18556357

SN - 0195-6108

VL - 29

SP - 1498

EP - 1504

JO - American Journal of Neuroradiology

JF - American Journal of Neuroradiology

IS - 8

ER -

White matter changes contribute to corpus callosum atrophy in the elderly: The LADIS study

Abstract

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