Wet Nanoscale Imaging and Testing of Polymersomes

Giuseppe Battaglia, Caterina LoPresti, Marzia Massignani, Nicholas J. Warren, Peter Jeppe Madsen, Simon Forster, Cvetilin Vasilev, Jamie K. Hobbs, Steven P. Armes, Somoyot Chirasatitsin, Adam J. Engler

Research output: Contribution to journalJournal articleResearchpeer-review


A facile methodology for the immobilization of polymersomes is demonstrated using ad-hoc synthesized, biotinylated copolymers or commercially available biotinylated phospholipids on streptavidin-decorated substrates. This allows the imaging of polymersomes using high-resolution techniques such as stimulated emission depletion microscopy and atomic force microscopy. This latter allows the gathering of other important functional parameters such as mechanical properties and surface topology, enabling characterization of these water-borne nanoparticles in wet conditions and hence in their natural environment. 
Original languageEnglish
Issue number14
Pages (from-to)2010-2015
Number of pages6
Publication statusPublished - 2011
Externally publishedYes


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