Wave-Block Due to a Threshold Gradient Underlies Limited Coordination in Pancreatic Islets

Morten Gram Pedersen, Mads Peter Sørensen

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Two models for coupled pancreatic β cells are used to investigate excited wave propagation in spatially inhomogeneous islets of Langerhans. The application concerns spatial variation of glucose concentration across the islet. A comprehensive model of coupled cells shows that wave blocking occurs as the conductance of adenosine triphosphate regulated potassium channels increases, corresponding to spatially decreasing glucose concentration. A simplified model based on a perturbed version of Fisher’s equation has been investigated using perturbation theory. We show that the perturbed Fisher’s equation likewise can exhibit wave blocking.
    Original languageEnglish
    JournalJournal of Biological Physics
    Volume34
    Issue number3-4
    Pages (from-to)425-432
    ISSN0092-0606
    DOIs
    Publication statusPublished - 2008

    Keywords

    • inhomogeneous media
    • nonlinear excitation waves
    • propagation failure
    • Calcium waves

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