Waist Circumference Adjusted for Body Mass Index and Intra-Abdominal Fat Mass

Tina Landsvig Berentzen, Lars Angquist, Anna Kotronen, Ronald Borra, Hannele Yki-Jarvinen, Patricia Iozzo, Riitta Parkkola, Pirjo Nuutila, Robert Ross, David B. Allison, Steven B. Heymsfield, Kim Overvad, Thorkild I. A. Sorensen, Marianne Uhre Jakobsen, François Blachier (Editor)

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Background: The association between waist circumference (WC) and mortality is particularly strong and direct when adjusted for body mass index (BMI). One conceivable explanation for this association is that WC adjusted for BMI is a better predictor of the presumably most harmful intra-abdominal fat mass (IAFM) than WC alone. We studied the prediction of abdominal subcutaneous fat mass (ASFM) and IAFM by WC alone and by addition of BMI as an explanatory factor. Methodology/Principal Findings: WC, BMI and magnetic resonance imaging data from 742 men and women who participated in clinical studies in Canada and Finland were pooled. Total adjusted squared multiple correlation coefficients (R-2) of ASFM and IAFM were calculated from multiple linear regression models with WC and BMI as explanatory variables. Mean BMI and WC of the participants in the pooled sample were 30 kg/m(2) and 102 cm, respectively. WC explained 29% of the variance in ASFM and 51% of the variance in IAFM. Addition of BMI to WC added 28% to the variance explained in ASFM, but only 1% to the variance explained in IAFM. Results in subgroups stratified by study center, sex, age, obesity level and type 2 diabetes status were not systematically different. Conclusion/Significance: The prediction of IAFM by WC is not improved by addition of BMI.
Original languageEnglish
Article numbere32213
JournalP L o S One
Issue number2
Number of pages6
Publication statusPublished - 2012
Externally publishedYes

Bibliographical note

Copyright 2012 Berentzen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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