Volumetric Raman chemical imaging of drug delivery systems

Roman Slipets, Oleksii Ilchenko*, Chiara Mazzoni, Fabio Tentor, Line Hagner Nielsen, Anja Boisen

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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The ability to image drug distribution inside a several hundred micron thick polymer matrix, encapsulated by a protective coating, would greatly contribute to the understanding of the performance and shortcomings of drug delivery devices. Here, we present an experimental framework for deep volumetric Raman imaging (dVRI), where common challenges such as low Raman cross section, fluorescence, and low transparency of samples are overcome. We apply dVRI to a selection of drug delivery forms, tablets with thin protective coatings and drug-loaded microdevices. We demonstrate three-dimensional visualization of the different drug/polymeric materials, constituting a drug delivery device, with imaging depth of 225 μm.
Original languageEnglish
JournalJournal of Raman Spectroscopy
Issue number7
Pages (from-to)1153-1159
Publication statusPublished - 2020


  • Chemometrics
  • Decomposition
  • Drug delivery systems
  • Raman imaging
  • Volumetric mapping

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