TY - JOUR
T1 - Visceral and Subcutaneous Adipose Tissue Assessed by Magnetic Resonance Imaging in Relation to Circulating Androgens, SHBG, and LH in Young Men
AU - Nielsen, Torben Leo
AU - Hagen, Claus
AU - Wraae, Kristian
AU - Brixen, Kim
AU - Petersen, Per Hyltoft
AU - Haug, Egil
AU - Larsen, Rasmus
AU - Andersen, Nina Marianne
PY - 2007
Y1 - 2007
N2 - Context: No large studies have examined the relation between circulating androgen levels and regional, abdominal adiposity in young men using magnetic resonance imaging (MRI). Objective: To study the role of visceral and subcutaneous adipose tissue (VAT and SAT) on circulating androgens and to examine the impact of obesity on androgen reference-intervals. Design, Setting, and Participants: Population-based study of 783 Danish, 20-29 year-old men. Ninety-eight men were ruled out of the healthy reference-population by predefined criteria related with hypogonadism. Total, central, and lower extremity fat mass (TFM, CFM, and LEFM) were assessed in all men by DXA and MRI was performed in 406 men. Main Outcome Measures: Total, bioavailable, and free testosterone (TT, BT, and FT), androstenedione (&8710;4AD), dihydrotestosterone (DHT), estradiol (E2), 2/TT-ratio, sex hormone-binding globulin (SHBG), and luteinizing hormone (LH). Results: Significant, inverse, linear relationships were observed between TT, BT, FT, DHT, SHBG and all DXA measures, whereas a positive correlation was found for the E2/TT-ratio. No associations were found for &8710;4AD. Independent, inverse relations between CFM and TT (p
AB - Context: No large studies have examined the relation between circulating androgen levels and regional, abdominal adiposity in young men using magnetic resonance imaging (MRI). Objective: To study the role of visceral and subcutaneous adipose tissue (VAT and SAT) on circulating androgens and to examine the impact of obesity on androgen reference-intervals. Design, Setting, and Participants: Population-based study of 783 Danish, 20-29 year-old men. Ninety-eight men were ruled out of the healthy reference-population by predefined criteria related with hypogonadism. Total, central, and lower extremity fat mass (TFM, CFM, and LEFM) were assessed in all men by DXA and MRI was performed in 406 men. Main Outcome Measures: Total, bioavailable, and free testosterone (TT, BT, and FT), androstenedione (&8710;4AD), dihydrotestosterone (DHT), estradiol (E2), 2/TT-ratio, sex hormone-binding globulin (SHBG), and luteinizing hormone (LH). Results: Significant, inverse, linear relationships were observed between TT, BT, FT, DHT, SHBG and all DXA measures, whereas a positive correlation was found for the E2/TT-ratio. No associations were found for &8710;4AD. Independent, inverse relations between CFM and TT (p
U2 - 10.1210/jc.2006-1847
DO - 10.1210/jc.2006-1847
M3 - Journal article
C2 - 17426100
SN - 0021-972X
VL - 92
SP - 2696
EP - 2705
JO - Journal of Clinical Endocrinology & Metabolism
JF - Journal of Clinical Endocrinology & Metabolism
IS - 7
ER -