Virus genomes reveal factors that spread and sustained the Ebola epidemic

Research output: Contribution to journalJournal article – Annual report year: 2017Researchpeer-review

Links

DOI

  • Author: Dudas, Gytis

    University of Edinburgh, United Kingdom

  • Author: Carvalho, Luiz Max

    University of Edinburgh, United Kingdom

  • Author: Bedford, Trevor

    Fred Hutchinson Cancer Research Center, United States

  • Author: Tatem, Andrew J.

    University of Southampton, United Kingdom

  • Author: Baele, Guy

    KU Leuven, Belgium

  • Author: Faria, Nuno R.

    University of Oxford, United Kingdom

  • Author: Park, Daniel J.

    Broad Institute of Harvard University and Massachusetts Institute of Technology, United States

  • Author: Ladner, Jason T.

    United States Army Medical Research Institute of Infectious Diseases, United States

  • Author: Arias Esteban, Armando

    Virology, Division for Diagnostics & Scientific Advice, National Veterinary Institute, Technical University of Denmark, Kemitorvet, 2800, Kgs. Lyngby, Denmark

  • Author: Asogun, Danny

    Irrua Specialist Teaching Hospital, Nigeria

  • Author: Bielejec, Filip

    KU Leuven, Belgium

  • Author: Caddy, Sarah L

    University of Cambridge, United Kingdom

  • Author: Cotten, Matthew

    Erasmus University Medical Center, Netherlands

  • Author: D'Ambrozio, Jonathan

    United States Army Medical Research Institute of Infectious Diseases, United States

  • Author: Dellicour, Simon

    KU Leuven, Belgium

  • Author: Di Caro, Antonino

    L. Spallanzani National Institute for Infectious Diseases, Italy

  • Author: Diclaro, Joseph W.

    Naval Medical Research Unit, Egypt

  • Author: Duraffour, Sophie

    Bernhard Nocht Institute for Tropical Medicine, Germany

  • Author: Elmore, Michael J.

    Public Health England, United Kingdom

  • Author: Fakoli, Lawrence S.

    Liberian Institute for Biomedical Research, Liberia

  • Author: Faye, Ousmane

    Institut Pasteur de Dakar, Senegal

  • Author: Gilbert, Merle L.

    United States Army Medical Research Institute of Infectious Diseases, United States

  • Author: Gevao, Sahr M.

    University of Sierra Leone, Sierra Leone

  • Author: Gire, Stephen

    Broad Institute of Harvard University and Massachusetts Institute of Technology, United States

  • Author: Gladden-Young, Adrianne

    Broad Institute of Harvard University and Massachusetts Institute of Technology, United States

  • Author: Gnirke, Andreas

    Broad Institute of Harvard University and Massachusetts Institute of Technology, United States

  • Author: Goba, Augustine

    Kenema Government Hospital, Sierra Leone

  • Author: Grant, Donald S.

    Kenema Government Hospital, Sierra Leone

  • Author: Haagmans, Bart L.

    Erasmus University Medical Center, Netherlands

  • Author: Hiscox, Julian A.

    University of Liverpool, United Kingdom

  • Author: Jah, Umaru

    University of Makeni, Sierra Leone

  • Author: Kugelman, Jeffrey R.

    United States Army Medical Research Institute of Infectious Diseases, United States

  • Author: Liu, Di

    Chinese Academy of Sciences, China

  • Author: Lu, Jia

    University of Cambridge, United Kingdom

  • Author: Malboeuf, Christine M.

    Broad Institute of Harvard University and Massachusetts Institute of Technology, United States

  • Author: Mate, Suzanne

    United States Army Medical Research Institute of Infectious Diseases, United States

  • Author: Matthews, David A.

    University of Bristol, United Kingdom

  • Author: Matranga, Christian B.

    Broad Institute of Harvard University and Massachusetts Institute of Technology, United States

  • Author: Meredith, Luke W.

    University of Cambridge, United Kingdom

  • Author: Qu, James

    Broad Institute of Harvard University and Massachusetts Institute of Technology, United States

  • Author: Quick, Joshua

    University of Birmingham, United Kingdom

  • Author: Pas, Suzan D.

    Erasmus University Medical Center, Netherlands

  • Author: Phan, My V. T.

    Erasmus University Medical Center, Netherlands

  • Author: Pollakis, Georgios

    University of Liverpool, United Kingdom

  • Author: Reusken, Chantal B.

    Erasmus University Medical Center, Netherlands

  • Author: Sanchez-Lockhart, Mariano

    United States Army Medical Research Institute of Infectious Diseases, United States

  • Author: Schaffner, Stephen F.

    Broad Institute of Harvard University and Massachusetts Institute of Technology, United States

  • Author: Schieffelin, John S.

    Tulane University, United States

  • Author: Sealfon, Rachel S.

    Broad Institute of Harvard University and Massachusetts Institute of Technology, United States

  • Author: Simon-Loriere, Etienne

    Institut Pasteur, France

  • Author: Smits, Saskia L.

    Erasmus University Medical Center, Netherlands

  • Author: Stoecker, Kilian

    Bundeswehr Institute of Microbiology, Germany

  • Author: Thorne, Lucy

    University of Cambridge, United Kingdom

  • Author: Tobin, Ekaete Alice

    Irrua Specialist Teaching Hospital, Nigeria

  • Author: Vandi, Mohamed A.

    Kenema Government Hospital, Sierra Leone

  • Author: J. Watson, Simon

    Wellcome Sanger Institute, United Kingdom

  • Author: West, Kendra

    Broad Institute of Harvard University and Massachusetts Institute of Technology, United States

  • Author: Whitmer, Shannon

    Centers for Disease Control and Prevention, United States

  • Author: Wiley, Michael R.

    United States Army Medical Research Institute of Infectious Diseases, United States

  • Author: Winnicki, Sarah M.

    Broad Institute of Harvard University and Massachusetts Institute of Technology, United States

  • Author: Wohl, Shirlee

    Broad Institute of Harvard University and Massachusetts Institute of Technology, United States

  • Author: Wolfel, Roman

    Bundeswehr Institute of Microbiology, Germany

  • Author: Yozwiak, Nathan L.

    Broad Institute of Harvard University and Massachusetts Institute of Technology, United States

  • Author: Andersen, Kristian G.

    The Scripps Research Institute, United States

  • Author: Blyden, Sylvia O.

    Sierra Leone Ministry of Social Welfare, Gender and Children's Affairs, Sierra Leone

  • Author: Bolay, Fatorma

    Liberian Institute for Biomedical Research, Liberia

  • Author: Carroll, Miles W.

    Public Health England, United Kingdom

  • Author: Dahn, Bernice

    Ministry of Health Liberia, Liberia

  • Author: Diallo, Boubacar

    World Health Organization Guinea, Guinea

  • Author: Formenty, Pierre

    World Health Organization, Switzerland

  • Author: Fraser, Christophe

    University of Oxford, United Kingdom

  • Author: Gao, George F.

    Chinese Academy of Sciences, China

  • Author: Garry, Robert F.

    Tulane University, United States

  • Author: Goodfellow, Ian

    University of Cambridge, United Kingdom

  • Author: Günther, Stephan

    Bernhard Nocht Institute for Tropical Medicine, Germany

  • Author: Happi, Christian T.

    Redeemer’s University, Nigeria

  • Author: Holmes, Edward C.

    University of Sydney, Australia

  • Author: Kargbo, Brima

    Ministry of Health and Sanitation, Sierra Leone

  • Author: Keïta, Sakoba

    Ministry of Health and Public Hygiene, Guinea

  • Author: Kellam, Paul

    Wellcome Sanger Institute, United Kingdom

  • Author: Koopmans, Marion P. G.

    Erasmus University Medical Center, Netherlands

  • Author: Kuhn, Jens H.

    National Institutes of Health, United States

  • Author: Loman, Nicholas J.

    University of Birmingham, United Kingdom

  • Author: Magassouba, N'Faly

    Gamal Abdel Nasser University of Conakry, Guinea

  • Author: Naidoo, Dhamari

    World Health Organization, Switzerland

  • Author: Nichol, Stuart T.

    Centers for Disease Control and Prevention, United States

  • Author: Nyenswah, Tolbert

    Ministry of Health Liberia, Liberia

  • Author: Palacios, Gustavo

    United States Army Medical Research Institute of Infectious Diseases, United States

  • Author: Pybus, Oliver G

    University of Oxford, United Kingdom

  • Author: Sabeti, Pardis C.

    Broad Institute of Harvard University and Massachusetts Institute of Technology, United States

  • Author: Sall, Amadou

    Institut Pasteur de Dakar, Senegal

  • Author: Stroher, Ute

    Centers for Disease Control and Prevention, United States

  • Author: Wurie, Isatta

    University of Sierra Leone, Sierra Leone

  • Author: Suchard, Marc A.

    University of California at Los Angeles, United States

  • Author: Lemey, Philippe

    KU Leuven, Belgium

  • Author: Rambaut, Andrew

    University of Edinburgh, United Kingdom

View graph of relations

The 2013-2016 West African epidemic caused by the Ebola virus was of unprecedented magnitude, duration and impact. Here we reconstruct the dispersal, proliferation and decline of Ebola virus throughout the region by analysing 1,610 Ebola virus genomes, which represent over 5% of the known cases. We test the association of geography, climate and demography with viral movement among administrative regions, inferring a classic 'gravity' model, with intense dispersal between larger and closer populations. Despite attenuation of international dispersal after border closures, cross-border transmission had already sown the seeds for an international epidemic, rendering these measures ineffective at curbing the epidemic. We address why the epidemic did not spread into neighbouring countries, showing that these countries were susceptible to substantial outbreaks but at lower risk of introductions. Finally, we reveal that this large epidemic was a heterogeneous and spatially dissociated collection of transmission clusters of varying size, duration and connectivity. These insights will help to inform interventions in future epidemics.
Original languageEnglish
JournalNature
Volume544
Issue number7650
Pages (from-to)309-315
ISSN0028-0836
DOIs
Publication statusPublished - 2017
CitationsWeb of Science® Times Cited: No match on DOI
Download as:
Download as PDF
Select render style:
APAAuthorCBE/CSEHarvardMLAStandardVancouverShortLong
PDF
Download as HTML
Select render style:
APAAuthorCBE/CSEHarvardMLAStandardVancouverShortLong
HTML
Download as Word
Select render style:
APAAuthorCBE/CSEHarvardMLAStandardVancouverShortLong
Word

ID: 132156692