Very high specific activity 66/68Ga from zinc targets for PET

J. W. Engle, V. Lopez-Rodriguez, R. E. Gaspar-Carcamo, H. F. Valdovinos, M. Valle-Gonzalez, F. Trejo-Ballado, Gregory W. Severin, T. E. Barnhart, R. J. Nickles, M. A. Avila-Rodriguez

Research output: Contribution to journalJournal articleResearchpeer-review


This work describes the production of very high specific activity 66/68Ga from natZn(p,n) and 66Zn(p,n) using proton irradiations between 7 and 16MeV, with emphasis on 66Ga for use with common bifunctional chelates. Principal radiometallic impurities are 65Zn from (p,x) and 67Ga from (p,n). Separation of radiogallium from target material is accomplished with cation exchange chromatography in hydrochloric acid solution. Efficient recycling of Zn target material is possible using electrodeposition of Zn from its chloride form, but these measures are not necessary to achieve high specific activity or near-quantitative radiolabeling yields from natural targets. Inductively coupled plasma mass spectroscopy (ICP-MS) measures less than 2ppb non-radioactive gallium in the final product, and the reactivity of 66Ga with common bifunctional chelates, decay corrected to the end of irradiation, is 740GBq/μmol (20Ci/μmol) using natural zinc as a target material. Recycling enriched 66Zn targets increased the reactivity of 66Ga with common bifunctional chelates. © 2012.
Original languageEnglish
JournalApplied Radiation and Isotopes
Issue number8
Pages (from-to)1792-1796
Number of pages5
Publication statusPublished - 2012
Externally publishedYes


  • Radiation
  • 66Ga
  • 68Ga
  • Cation exchange
  • Eclipse
  • PETtrace
  • Zn electrodeposition
  • Bifunctional
  • Cation exchange chromatography
  • Cation exchanges
  • Efficient recycling
  • End of irradiations
  • Hydrochloric acid solution
  • Inductively coupled plasma mass spectroscopies
  • Natural targets
  • Radiolabeling
  • Specific activity
  • Target materials
  • Chelation
  • Chlorine compounds
  • Chromatography
  • Hydrochloric acid
  • Inductively coupled plasma
  • Mass spectrometers
  • Mass spectrometry
  • Positive ions
  • Recycling
  • Zinc
  • Gallium
  • chelate
  • chloride
  • gallium
  • gallium 66
  • gallium 68
  • hydrochloric acid
  • unclassified drug
  • zinc 65
  • article
  • ion exchange chromatography
  • isotope labeling
  • mass spectrometry
  • nuclear fuel reprocessing
  • positron emission tomography
  • priority journal
  • proton radiation
  • quantitative analysis
  • radiosensitivity
  • recycle fermentation
  • separation technique
  • Gallium Radioisotopes
  • Positron-Emission Tomography
  • J41CSQ7QDS Zinc


Dive into the research topics of 'Very high specific activity 66/68Ga from zinc targets for PET'. Together they form a unique fingerprint.

Cite this