Variants of alpha-1-antitrypsin

Sanne Schoffelen (Inventor), Bjørn Gunnar Voldborg (Inventor), Gerry McElvaney (Inventor)

Research output: Patent

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Provided are variants of alpha-1-antitrypsin comprising mutations which render the variants oxidation- as well as protease-resistant, polynucleotides encoding said variants, methods of producing the variants and the variants for use in the treatment of alpha-1-antitrypsin deficiency, cystic fibrosis and chronic obstructive pulmonary disease.

Original languageEnglish
IPCC07K 14/ 81 A I
Patent numberWO2023083859
Filing date09/11/2021
Country/TerritoryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date09/11/2021
Priority numberEP20210207135
Publication statusPublished - 19 May 2023


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