Abstract
Provided are variants of alpha-1-antitrypsin comprising mutations which render the variants oxidation- as well as protease-resistant, polynucleotides encoding said variants, methods of producing the variants and the variants for use in the treatment of alpha-1-antitrypsin deficiency, cystic fibrosis and chronic obstructive pulmonary disease.
| Original language | English |
|---|---|
| IPC | C07K 14/ 81 A I |
| Patent number | WO2023083859 |
| Filing date | 09/11/2021 |
| Country/Territory | International Bureau of the World Intellectual Property Organization (WIPO) |
| Priority date | 09/11/2021 |
| Priority number | EP20210207135 |
| Publication status | Published - 19 May 2023 |