Variants of acetylserotonin o-methyltransferase and uses thereof

Hao Luo (Inventor)

Research output: Patent

105 Downloads (Pure)


Described herein are variants of acetylserotonin O-methyltransferase (ASMT) as well as vectors and recombinant microbial host cells expressing such ASMT variant and their use in producing melatonin and related compounds. Preferred ASMT variants provide for a higher turnover of N-acetylserotonin into melatonin.

Original languageEnglish
IPCC12P 17/ 10 A I
Patent numberWO2017202897
Filing date30/11/2017
Country/TerritoryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date24/05/2016
Priority numberEP20160171032
Publication statusPublished - 30 Nov 2017


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