Abstract
We describe here the sequence and gene organization of a new glycopeptide resistance operon (vanO) in Rhodococcus equi from soil. The vanO operon has low homology to enterococcal van operons and harbors a vanHOX cluster transcribed in the direction opposite that of the vanS-vanR regulatory system and composed of three open reading frames with unknown function. This finding has clinical interest, since glycopeptides are used to treat R. equi infections and resistance has been reported in clinical isolates. Copyright © 2014, American Society for Microbiology. All Rights Reserved.
| Original language | English |
|---|---|
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 58 |
| Issue number | 3 |
| Pages (from-to) | 1768-1770 |
| Number of pages | 3 |
| ISSN | 0066-4804 |
| DOIs | |
| Publication status | Published - 2014 |
| Externally published | Yes |
Keywords
- Pharmacology (medical)
- Pharmacology
- Infectious Diseases
- glycopeptide
- rifampicin
- RNA 16S
- vancomycin
- Actinomycetales infection
- antibiotic resistance
- article
- bacterial gene
- bacterial genome
- bacterium isolate
- controlled study
- gene sequence
- genetic organization
- nonhuman
- nucleotide sequence
- operon
- priority journal
- Rhodococcus equi
- soil microflora
- vanO gene
- Base Sequence
- Drug Resistance, Bacterial
- Genes, Bacterial
- Glycopeptides
- Molecular Sequence Data
- Open Reading Frames
- Operon
- R Factors
- Mechanisms of Resistance
- Genetics - General
- Pathology - Therapy
- Pharmacology - General
- Physiology and biochemistry of bacteria
- Genetics of bacteria and viruses
- Chemotherapy - General, methods and metabolism
- Chemotherapy - Antibacterial agents
- Bacteria, Eubacteria, Microorganisms
- gene organization
- soil sample
