Vanadium-and chromium-catalyzed dehydrogenative synthesis of imines from alcohols and amines

Yulong Miao, Simone Vestermann Samuelsen, Robert Madsen*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review


Vanadium(IV) tetraphenylporphyrin dichloride and chromium(III) tetraphenylporphyrin chloride have been developed as catalysts for the acceptorless dehydrogenation of alcohols. The catalysts have been applied to the direct synthesis of imines in overall good yields from a variety of alcohols and amines. The transformations are proposed to proceed by metal−ligand bifunctional pathways with an outer-sphere transfer of two hydrogen atoms from the alcohol to the metal porphyrin complexes. The results show that vanadium and chromium catalysts can also be employed for the dehydrogenation of alcohols with the release of hydrogen gas, and they may represent valuable alternatives to other catalysts based on Earth-abundant metals.

Original languageEnglish
Issue number9
Pages (from-to)1328-1335
Publication statusPublished - 2021

Bibliographical note

Funding Information:
Y.M. and S.V.S. gratefully acknowledge the China Scholarship Council (CSC) and the Technical University of Denmark, respectively, for PhD fellowships. In addition, we thank the Independent Research Fund Denmark—Technology and Production Sciences for financial support.

Publisher Copyright:
© 2021 American Chemical Society


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