Validation of a Simulation Model Describing the Glucose-Insulin-Glucagon Pharmacodynamics in Patients with Type 1 Diabetes

Sabrina Lyngbye Wendt; Ajenthen Ranjan; Jan Kloppenborg Møller; Signe Schmidt; Carsten Boye Knudsen; Jens Juul Holst; Sten Madsbad; Henrik Madsen; Kirsten Nørgaard; John Bagterp Jørgensen

Validation of a Simulation Model Describing the Glucose-Insulin-Glucagon Pharmacodynamics in Patients with Type 1 Diabetes

Sabrina Lyngbye Wendt, Ajenthen Ranjan, Jan Kloppenborg Møller, Signe Schmidt, Carsten Boye Knudsen, Jens Juul Holst, Sten Madsbad, Henrik Madsen, Kirsten Nørgaard, John Bagterp Jørgensen

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Abstract

Currently, no consensus exists on a model describing endogenous glucose production (EGP) as a function of glucagon concentrations. Reliable simulations to determine
the glucagon dose preventing or treating hypoglycemia or to tune a dual-hormone artificial pancreas control algorithm need a validated glucoregulatory model including the effect of glucagon.

Original language	English
Publication date	2017
Number of pages	1
Publication status	Published - 2017
Event	Advanced Technology and Treatments for Diabetes 2017 - Paris, France Duration: 15 Feb 2017 → 18 Feb 2017

Conference

Conference	Advanced Technology and Treatments for Diabetes 2017
Country/Territory	France
City	Paris
Period	15/02/2017 → 18/02/2017

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Wendt, S. L., Ranjan, A., Møller, J. K., Schmidt, S., Boye Knudsen, C., Holst, J. J., Madsbad, S., Madsen, H., Nørgaard, K., & Jørgensen, J. B. (2017). Validation of a Simulation Model Describing the Glucose-Insulin-Glucagon Pharmacodynamics in Patients with Type 1 Diabetes. Poster session presented at Advanced Technology and Treatments for Diabetes 2017, Paris, France.

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title = "Validation of a Simulation Model Describing the Glucose-Insulin-Glucagon Pharmacodynamics in Patients with Type 1 Diabetes",

abstract = "Currently, no consensus exists on a model describing endogenous glucose production (EGP) as a function of glucagon concentrations. Reliable simulations to determinethe glucagon dose preventing or treating hypoglycemia or to tune a dual-hormone artificial pancreas control algorithm need a validated glucoregulatory model including the effect of glucagon.",

author = "Wendt, {Sabrina Lyngbye} and Ajenthen Ranjan and M{\o}ller, {Jan Kloppenborg} and Signe Schmidt and {Boye Knudsen}, Carsten and Holst, {Jens Juul} and Sten Madsbad and Henrik Madsen and Kirsten N{\o}rgaard and J{\o}rgensen, {John Bagterp}",

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language = "English",

note = "Advanced Technology and Treatments for Diabetes 2017, ATTD 2017 ; Conference date: 15-02-2017 Through 18-02-2017",

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T1 - Validation of a Simulation Model Describing the Glucose-Insulin-Glucagon Pharmacodynamics in Patients with Type 1 Diabetes

AU - Wendt, Sabrina Lyngbye

AU - Ranjan, Ajenthen

AU - Møller, Jan Kloppenborg

AU - Schmidt, Signe

AU - Boye Knudsen, Carsten

AU - Holst, Jens Juul

AU - Madsbad, Sten

AU - Madsen, Henrik

AU - Nørgaard, Kirsten

AU - Jørgensen, John Bagterp

PY - 2017

Y1 - 2017

N2 - Currently, no consensus exists on a model describing endogenous glucose production (EGP) as a function of glucagon concentrations. Reliable simulations to determinethe glucagon dose preventing or treating hypoglycemia or to tune a dual-hormone artificial pancreas control algorithm need a validated glucoregulatory model including the effect of glucagon.

AB - Currently, no consensus exists on a model describing endogenous glucose production (EGP) as a function of glucagon concentrations. Reliable simulations to determinethe glucagon dose preventing or treating hypoglycemia or to tune a dual-hormone artificial pancreas control algorithm need a validated glucoregulatory model including the effect of glucagon.

M3 - Poster

T2 - Advanced Technology and Treatments for Diabetes 2017

Y2 - 15 February 2017 through 18 February 2017

ER -

Validation of a Simulation Model Describing the Glucose-Insulin-Glucagon Pharmacodynamics in Patients with Type 1 Diabetes

Abstract

Conference

UN SDGs

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