Abstract
In European fish farms there is evidence of enteric red mouth disease (ERM) outbreaks in
previously vaccinated farmed fish. It has been suggested that the occurrence of a Yersinia ruckeri
variant (biotype 2) may explain this situation. Recent development of commercial vaccines has
included both biotype 1 and 2. In this study, the specificity of immune protection extended by three
commercial vaccines viz; AQUAVAC ERM® Intervet Schering Plough (based on biotype 1 only),
ERMOGEN VET® Novartis (based on biotype 1 only) and AQUAVAC RELERA® Intervet
Schering Plough (based on both biotype 1and 2) developed against ERM was investigated
following intraperitoneal (IP) challenge with Yersinia ruckeri serotype1 biotype 2. Fish were
immersion vaccinated for 30 s and challenged 2, 4 and 6 months post vaccination. The onset and
severity of various pathological lesions along with their disappearance during the course of disease
was also carried out to evaluate the protective index conferred by three different vaccines. After IP
challenge, the overall best relative percentage survival was observed in AQUAVAC RELERA®
followed by ERMOGEN VET® with least survival rates in AQUAVAC ERM® among all
vaccinated groups. Interestingly a marginal better immune protection was observed between
AQUAVAC RELERA® and ERMOGEN VET® vaccinated group during the last two challenge trial.
The onset and severity of pathological lesions observed during challenge 2 (i.e. 4 month post
vaccination) suggested a beneficial efficacy shown by AQUAVAC RELERA® in terms of milder
and lesser degree of certain pathological lesions like haemorrhages in or around the buccal cavity,
base of fins and intestines, when compared to ERMOGEN VET®, AQUAVAC ERM® vaccinated
group and Yersinia ruckeri (BT2) infected group.
Original language | English |
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Title of host publication | Book of abstracts |
Editors | Per W. Kania, Kurt Buchmann |
Number of pages | 18 |
Place of Publication | Frederiksberg |
Publisher | DAFINET |
Publication date | 2011 |
Publication status | Published - 2011 |
Event | DAFINET Workshop: The Ontogeny of the Immune System of Fish - Status and Future Challenges - Siemsens Gaard, Svaneke, Denmark Duration: 3 May 2011 → 5 May 2011 |
Workshop
Workshop | DAFINET Workshop |
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Location | Siemsens Gaard |
Country/Territory | Denmark |
City | Svaneke |
Period | 03/05/2011 → 05/05/2011 |