UV-guided isolation of verrucine A and B, novel quinazolines from Penicillium verrucosum structurally related to anacine from P. aurantiogriseum

Thomas Ostenfeld Larsen, Henrik Franzyk, Søren Rosendal Jensen

    Research output: Contribution to journalJournal articleResearchpeer-review


    Two novel quinazolines, verrucine A and B, have been isolated as a major and a minor metabolite of Penicillium verrucosum, respectively. Both are condensates of one mole each of anthranilic acid, phenylalanine and glutamine. The structures were elucidated by spectroscopic methods and the two compounds were found to be epimers. The spectroscopic data for the ostensible benzodiazepine anacine reported from Penicillium aurantiogriseum, composed of one mole each of anthranilic acid, leucine and glutamine, appeared very similar to those of verrucine A. Therefore a revised quinazoline structure for anacine is proposed.
    Original languageEnglish
    JournalJournal of Natural Products
    Issue number11
    Pages (from-to)1578-1580
    Publication statusPublished - 1999

    Cite this