Using THz-ATR Spectroscopy for Detecting Mimicked Interstitial Fluid Flow in ex vivo Skin

Lorenza Pia Foglia; Bjørn Hübschmann Mølvig; Mads Ehrhorn; Miriam Galbiati; Simon Jappe Lange; Peter Uhd Jepsen

doi:10.1109/IRMMW-THz57677.2023.10299315

Using THz-ATR Spectroscopy for Detecting Mimicked Interstitial Fluid Flow in ex vivo Skin

Lorenza Pia Foglia, Bjørn Hübschmann Mølvig, Mads Ehrhorn, Miriam Galbiati, Simon Jappe Lange, Peter Uhd Jepsen

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

Abstract

Biomolecular detection in the skin’s interstitial fluid (ISF) based on THz-ATR spectroscopy holds a plethora of applications and several challenges, both from an experimental and a computational point of view. We propose an experimental procedure for embedding a liquid solution in ex vivo pig skin samples that mimics the ISF’s flow from the hypodermis to the viable epidermis. The contrast is shown in the reflectivity and the reproducibility is assessed with respect to sources of variability in the experimental procedure. An optimized protocol represents a steppingstone to further studies towards in vivo THz biosensing.

Original language	English
Title of host publication	Proceedings of 48^th International Conference on Infrared, Millimeter, and Terahertz Waves
Number of pages	2
Publisher	IEEE
Publication date	22 Sept 2023
Article number	10299315
ISBN (Print)	979-8-3503-3661-0
DOIs	https://doi.org/10.1109/IRMMW-THz57677.2023.10299315
Publication status	Published - 22 Sept 2023
Event	48^th International Conference on Infrared, Millimeter, and Terahertz Waves - Montreal, Canada Duration: 17 Sept 2023 → 22 Sept 2023

Conference

Conference	48^th International Conference on Infrared, Millimeter, and Terahertz Waves
Country/Territory	Canada
City	Montreal
Period	17/09/2023 → 22/09/2023

Keywords

Reflectivity
Spectroscopy
In vivo
Protocols
Liquids
MIMICs
Fluid flow

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10.1109/IRMMW-THz57677.2023.10299315

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title = "Using THz-ATR Spectroscopy for Detecting Mimicked Interstitial Fluid Flow in ex vivo Skin",

abstract = "Biomolecular detection in the skin{\textquoteright}s interstitial fluid (ISF) based on THz-ATR spectroscopy holds a plethora of applications and several challenges, both from an experimental and a computational point of view. We propose an experimental procedure for embedding a liquid solution in ex vivo pig skin samples that mimics the ISF{\textquoteright}s flow from the hypodermis to the viable epidermis. The contrast is shown in the reflectivity and the reproducibility is assessed with respect to sources of variability in the experimental procedure. An optimized protocol represents a steppingstone to further studies towards in vivo THz biosensing.",

keywords = "Reflectivity, Spectroscopy, In vivo, Protocols, Liquids, MIMICs, Fluid flow",

author = "Foglia, {Lorenza Pia} and M{\o}lvig, {Bj{\o}rn H{\"u}bschmann} and Mads Ehrhorn and Miriam Galbiati and Lange, {Simon Jappe} and Jepsen, {Peter Uhd}",

year = "2023",

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doi = "10.1109/IRMMW-THz57677.2023.10299315",

language = "English",

isbn = "979-8-3503-3661-0",

booktitle = "Proceedings of 48th International Conference on Infrared, Millimeter, and Terahertz Waves",

publisher = "IEEE",

address = "United States",

note = "48<sup>th</sup> International Conference on Infrared, Millimeter, and Terahertz Waves, 2023 IRMMW-THz ; Conference date: 17-09-2023 Through 22-09-2023",

}

Foglia, LP , Mølvig, BH , Ehrhorn, M, Galbiati, M, Lange, SJ & Jepsen, PU 2023, Using THz-ATR Spectroscopy for Detecting Mimicked Interstitial Fluid Flow in ex vivo Skin. in Proceedings of 48^th International Conference on Infrared, Millimeter, and Terahertz Waves., 10299315, IEEE, 48^th International Conference on Infrared, Millimeter, and Terahertz Waves, Montreal, Quebec, Canada, 17/09/2023. https://doi.org/10.1109/IRMMW-THz57677.2023.10299315

Using THz-ATR Spectroscopy for Detecting Mimicked Interstitial Fluid Flow in ex vivo Skin. / Foglia, Lorenza Pia ; Mølvig, Bjørn Hübschmann ; Ehrhorn, Mads et al.
Proceedings of 48^th International Conference on Infrared, Millimeter, and Terahertz Waves. IEEE, 2023. 10299315.

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

TY - GEN

T1 - Using THz-ATR Spectroscopy for Detecting Mimicked Interstitial Fluid Flow in ex vivo Skin

AU - Foglia, Lorenza Pia

AU - Mølvig, Bjørn Hübschmann

AU - Ehrhorn, Mads

AU - Galbiati, Miriam

AU - Lange, Simon Jappe

AU - Jepsen, Peter Uhd

PY - 2023/9/22

Y1 - 2023/9/22

N2 - Biomolecular detection in the skin’s interstitial fluid (ISF) based on THz-ATR spectroscopy holds a plethora of applications and several challenges, both from an experimental and a computational point of view. We propose an experimental procedure for embedding a liquid solution in ex vivo pig skin samples that mimics the ISF’s flow from the hypodermis to the viable epidermis. The contrast is shown in the reflectivity and the reproducibility is assessed with respect to sources of variability in the experimental procedure. An optimized protocol represents a steppingstone to further studies towards in vivo THz biosensing.

AB - Biomolecular detection in the skin’s interstitial fluid (ISF) based on THz-ATR spectroscopy holds a plethora of applications and several challenges, both from an experimental and a computational point of view. We propose an experimental procedure for embedding a liquid solution in ex vivo pig skin samples that mimics the ISF’s flow from the hypodermis to the viable epidermis. The contrast is shown in the reflectivity and the reproducibility is assessed with respect to sources of variability in the experimental procedure. An optimized protocol represents a steppingstone to further studies towards in vivo THz biosensing.

KW - Reflectivity

KW - Spectroscopy

KW - In vivo

KW - Protocols

KW - Liquids

KW - MIMICs

KW - Fluid flow

U2 - 10.1109/IRMMW-THz57677.2023.10299315

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BT - Proceedings of 48th International Conference on Infrared, Millimeter, and Terahertz Waves

PB - IEEE

T2 - 48<sup>th</sup> International Conference on Infrared, Millimeter, and Terahertz Waves

Y2 - 17 September 2023 through 22 September 2023

ER -

Using THz-ATR Spectroscopy for Detecting Mimicked Interstitial Fluid Flow in ex vivo Skin

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