Using microcantilever sensors to measure poly(lactic-co-glycolic acid) plasticization by moisture uptake

Gustavo Marcati A. Alves; Sanjukta Bose-Goswami; Ronaldo D. Mansano; Anja Boisen

doi:10.1016/j.polymertesting.2017.12.017

Using microcantilever sensors to measure poly(lactic-co-glycolic acid) plasticization by moisture uptake

Gustavo Marcati A. Alves^*, Sanjukta Bose-Goswami, Ronaldo D. Mansano, Anja Boisen

^*Corresponding author for this work

University of São Paulo

Research output: Contribution to journal › Journal article › Research › peer-review

146 Downloads (Pure)

Abstract

Polymeric materials absorb water when exposed to humidity or in contact with aqueous solutions. The polymer and water molecules interact, changing the physicochemical parameters of the material; the most noticeable effect is a decreased glass transition temperature (T_g), known as plasticization. We used microcantilever sensors to measure the Tg versus moisture content in poly(lactic-co-glycolic acid) (PLGA), a biodegradable polymer used in implants and as a drug carrier. We demonstrate a concomitant measurement of the mass absorption and T_g using nanograms of material and an inexpensive setup. The standard deviation of T_g for this system was 0.025 °C, and the variation in T_g with respect to a 1% RH change was clearly resolved. The decrease in the T_g of PLGA was linear (R2 = 0.99) at a rate of 6.03 ± 0.57 °C per mass% of water absorbed. The initial dry T_g of PLGA was extrapolated to 41.24 ± 0.07 °C.

Original language	English
Journal	Polymer Testing
Volume	65
Pages (from-to)	407-413
Number of pages	7
ISSN	0142-9418
DOIs	https://doi.org/10.1016/j.polymertesting.2017.12.017
Publication status	Published - 2018

Keywords

Microcantilever
Thermal analysis
Plasticization
Poly(lactic-co-glycolic acid)
Glass transition

Access to Document

10.1016/j.polymertesting.2017.12.017

Pp Using microcantilever sensors to measure poly lactic co glycolic acidAccepted author manuscript, 736 KBLicence: CC BY-NC-ND

OpenUrl availability

Full text

Cite this

@article{e6dd49a0731e4173b0622b1b4ca63e10,

title = "Using microcantilever sensors to measure poly(lactic-co-glycolic acid) plasticization by moisture uptake",

abstract = "Polymeric materials absorb water when exposed to humidity or in contact with aqueous solutions. The polymer and water molecules interact, changing the physicochemical parameters of the material; the most noticeable effect is a decreased glass transition temperature (Tg), known as plasticization. We used microcantilever sensors to measure the Tg versus moisture content in poly(lactic-co-glycolic acid) (PLGA), a biodegradable polymer used in implants and as a drug carrier. We demonstrate a concomitant measurement of the mass absorption and Tg using nanograms of material and an inexpensive setup. The standard deviation of Tg for this system was 0.025 °C, and the variation in Tg with respect to a 1% RH change was clearly resolved. The decrease in the Tg of PLGA was linear (R2 = 0.99) at a rate of 6.03 ± 0.57 °C per mass% of water absorbed. The initial dry Tg of PLGA was extrapolated to 41.24 ± 0.07 °C.",

keywords = "Microcantilever, Thermal analysis, Plasticization, Poly(lactic-co-glycolic acid), Glass transition",

author = "Alves, {Gustavo Marcati A.} and Sanjukta Bose-Goswami and Mansano, {Ronaldo D.} and Anja Boisen",

year = "2018",

doi = "10.1016/j.polymertesting.2017.12.017",

language = "English",

volume = "65",

pages = "407--413",

journal = "Polymer Testing",

issn = "0142-9418",

publisher = "Elsevier",

}

TY - JOUR

T1 - Using microcantilever sensors to measure poly(lactic-co-glycolic acid) plasticization by moisture uptake

AU - Alves, Gustavo Marcati A.

AU - Bose-Goswami, Sanjukta

AU - Mansano, Ronaldo D.

AU - Boisen, Anja

PY - 2018

Y1 - 2018

N2 - Polymeric materials absorb water when exposed to humidity or in contact with aqueous solutions. The polymer and water molecules interact, changing the physicochemical parameters of the material; the most noticeable effect is a decreased glass transition temperature (Tg), known as plasticization. We used microcantilever sensors to measure the Tg versus moisture content in poly(lactic-co-glycolic acid) (PLGA), a biodegradable polymer used in implants and as a drug carrier. We demonstrate a concomitant measurement of the mass absorption and Tg using nanograms of material and an inexpensive setup. The standard deviation of Tg for this system was 0.025 °C, and the variation in Tg with respect to a 1% RH change was clearly resolved. The decrease in the Tg of PLGA was linear (R2 = 0.99) at a rate of 6.03 ± 0.57 °C per mass% of water absorbed. The initial dry Tg of PLGA was extrapolated to 41.24 ± 0.07 °C.

AB - Polymeric materials absorb water when exposed to humidity or in contact with aqueous solutions. The polymer and water molecules interact, changing the physicochemical parameters of the material; the most noticeable effect is a decreased glass transition temperature (Tg), known as plasticization. We used microcantilever sensors to measure the Tg versus moisture content in poly(lactic-co-glycolic acid) (PLGA), a biodegradable polymer used in implants and as a drug carrier. We demonstrate a concomitant measurement of the mass absorption and Tg using nanograms of material and an inexpensive setup. The standard deviation of Tg for this system was 0.025 °C, and the variation in Tg with respect to a 1% RH change was clearly resolved. The decrease in the Tg of PLGA was linear (R2 = 0.99) at a rate of 6.03 ± 0.57 °C per mass% of water absorbed. The initial dry Tg of PLGA was extrapolated to 41.24 ± 0.07 °C.

KW - Microcantilever

KW - Thermal analysis

KW - Plasticization

KW - Poly(lactic-co-glycolic acid)

KW - Glass transition

U2 - 10.1016/j.polymertesting.2017.12.017

DO - 10.1016/j.polymertesting.2017.12.017

M3 - Journal article

SN - 0142-9418

VL - 65

SP - 407

EP - 413

JO - Polymer Testing

JF - Polymer Testing

ER -

Using microcantilever sensors to measure poly(lactic-co-glycolic acid) plasticization by moisture uptake

Abstract

Keywords

Access to Document

OpenUrl availability

Fingerprint

Cite this