Using Genome-scale Models to Predict Biological Capabilities

Edward J. O’Brien, Jonathan M. Monk, Bernhard O. Palsson

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Abstract

Constraint-based reconstruction and analysis (COBRA) methods at the genome scale have been under development since the first whole-genome sequences appeared in the mid-1990s. A few years ago, this approach began to demonstrate the ability to predict a range of cellular functions, including cellular growth capabilities on various substrates and the effect of gene knockouts at the genome scale. Thus, much interest has developed in understanding and applying these methods to areas such as metabolic engineering, antibiotic design, and organismal and enzyme evolution. This Primer will get you started.
Original languageEnglish
JournalCELL
Volume161
Issue number5
Pages (from-to)971-987
Number of pages17
ISSN0092-8674
DOIs
Publication statusPublished - 2015

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