Use of genome-scale microbial models for metabolic engineering

Kiran Raosaheb Patil, M. Åkesson, Jens Nielsen

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Metabolic engineering serves as an integrated approach to design new cell factories by providing rational design procedures and valuable mathematical and experimental tools. Mathematical models have an important role for phenotypic analysis, but can also be used for the design of optimal metabolic network structures. The major challenge for metabolic engineering in the post-genomic era is to broaden its design methodologies to incorporate genome-scale biological data. Genome-scale stoichiometric models of microorganisms represent a first step in this direction.
    Original languageEnglish
    JournalCurrent Opinion in Biotechnology
    Volume15
    Issue number1
    Pages (from-to)64-69
    ISSN0958-1669
    DOIs
    Publication statusPublished - 2004

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