TY - JOUR
T1 - Use of genome-scale microbial models for metabolic engineering
AU - Patil, Kiran Raosaheb
AU - Åkesson, M.
AU - Nielsen, Jens
PY - 2004
Y1 - 2004
N2 - Metabolic engineering serves as an integrated approach to design new cell factories by providing rational design procedures and valuable mathematical and experimental tools. Mathematical models have an important role for phenotypic analysis, but can also be used for the design of optimal metabolic network structures. The major challenge for metabolic engineering in the post-genomic era is to broaden its design methodologies to incorporate genome-scale biological data. Genome-scale stoichiometric models of microorganisms represent a first step in this direction.
AB - Metabolic engineering serves as an integrated approach to design new cell factories by providing rational design procedures and valuable mathematical and experimental tools. Mathematical models have an important role for phenotypic analysis, but can also be used for the design of optimal metabolic network structures. The major challenge for metabolic engineering in the post-genomic era is to broaden its design methodologies to incorporate genome-scale biological data. Genome-scale stoichiometric models of microorganisms represent a first step in this direction.
U2 - 10.1016/j.copbio.2003.11.003
DO - 10.1016/j.copbio.2003.11.003
M3 - Journal article
SN - 0958-1669
VL - 15
SP - 64
EP - 69
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
IS - 1
ER -