Use of a new glass microfibre histamine release method to study the modulation of the host response in human schistosomiasis mansoni. Individuals with different degrees of exposure to the disease show differing antibody biological function

M.Z. Satti, F. Ebbesen, B. Vennervald, Peter Lind, H. Ghalib, S. Sulaiman, A. Daffalla, P.S. Skov

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    A new glass microfibre histamine release method was used to study the modulation of the host response in human schistosomiasis mansoni to improve our understanding of the role of basophils in the development of immunity in schistosomiasis mansoni. The histamine release from umbilical cord blood basophils sensitized with sera from Sudanese individuals infected with Schistosoma mansoni was measured. Schistosomiasis sera (n=113) were able to passively sensitize basophils and induce a positive histamine release in response to whole worm homogenate (WWH)(chi(2)=40.5, P
    Original languageEnglish
    JournalTropical Medicine & International Health
    Volume1
    Issue number5
    Pages (from-to)655-666
    ISSN1360-2276
    DOIs
    Publication statusPublished - 1996

    Keywords

    • resistance
    • cord blood
    • schistosomiasis
    • basophils
    • histamine

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