Use-Dependent Inhibition of Synaptic Transmission by the Secretion of Intravesicularly Accumulated Antipsychotic Drugs

Carsten H. Tischbirek, Eva M. Wenzel, Fang Zheng, Tobias Huth, Davide Amato, Stefan Trapp, Annette Denker, Oliver Welzel, Katharina Lueke, Alexei Svetlitchny, Manfred Rauh, Janina Deusser, Annemarie Schwab, Silvio O. Rizzoli, Andreas W. Henkel, Christian P. Müller, Christian Alzheimer, Johannes Kornhuber, Teja W. Groemer

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Tischbirek et al. find that weak-base antipsychotic drugs are accumulated in synaptic vesicles and are secreted upon exocytosis, leading to increased extracellular drug concentrations following neuronal activity. The secretion of the drugs in turn inhibits synaptic transmission in a use-dependent manner.
Original languageEnglish
JournalNeuron
Volume74
Issue number5
Pages (from-to)830-844
ISSN0896-6273
DOIs
Publication statusPublished - 2012

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