Updating the asymmetric osmium-catalyzed dihydroxylation (AD) mnemonic. Q2MM modeling and new kinetic measurements

Peter Fristrup, David Ackland Tanner, Per-Ola Norrby

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The mnemonic device for predicting stereoselectivities in the Sharpless asymmetric dihydroxylation (AD) reaction has been updated based on extensive computational studies. Kinetic measurements from competition reactions validate the new proposal. The interactions responsible for the high stereoselectivity in the title reaction are analyzed in detail and mapped onto the mnemonic device.
Original languageEnglish
JournalChirality
Volume15
Issue number4
Pages (from-to)360-368
ISSN0899-0042
DOIs
Publication statusPublished - 2003

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