Upconversion raster scanning microscope for long-wavelength infrared imaging of breast cancer microcalcifications

Yu-Pei Tseng*, Pascaline Bouzy, Christian Pedersen, Nick Stone, Peter Tidemand-Lichtenberg

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Long-wavelength identification of microcalcifications in breast cancer tissue is demonstrated using a novel upconversion raster scanning microscope. The system consists of quantum cascade lasers (QCL) for illumination and an upconversion system for efficient, high-speed detection using a silicon detector. Absorbance spectra and images of regions of ductal carcinoma in situ (DCIS) from the breast have been acquired using both upconversion and Fourier-transform infrared (FTIR) systems. The spectral images are compared and good agreement is found between the upconversion and the FTIR systems. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
Original languageEnglish
JournalBiomedical Optics Express
Volume9
Issue number10
Pages (from-to)4979-4987
ISSN2156-7085
DOIs
Publication statusPublished - 2018

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