Unraveling cryptic chemistry in black aspergilli

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    Abstract

    The black aspergilli constitute an important group of species, both for their use in the biotechnological industry, and since they account for some of the most widespread food and feed contaminants. Most recently we have characterized the full biosynthetic pathway of the antibiotic yanuthone D from the industrially workhorse Aspergillus niger.1 On top of that we have presented a method for sclerotium induction, whereby we have reported sclerotia formation for the first time in seven black aspergilli, including A. niger.2 Thorough investigation by UHPLC-DAD-HRMS of fungal extracts, with and without sclerotia formation, have revealed a highly regulated metabolic profile for a number of species. We present this as an approach for the discovery of novel secondary metabolites from otherwise silent pathways.
    Original languageEnglish
    JournalPlanta Medica
    Volume80
    Issue number10
    ISSN0032-0943
    DOIs
    Publication statusPublished - 2014
    EventAmerican Society of Pharmacognosy 2014 Annual Meeting - Oxford, Mississippi, United States
    Duration: 2 Aug 20146 Oct 2014

    Conference

    ConferenceAmerican Society of Pharmacognosy 2014 Annual Meeting
    CountryUnited States
    CityOxford, Mississippi
    Period02/08/201406/10/2014

    Keywords

    • biotechnological industry
    • sclerotia formation
    • unraveling cryptic chemistry
    • Fungi Plantae (Fungi, Microorganisms, Nonvascular Plants, Plants) - Fungi Imperfecti or Deuteromycetes [15500] Aspergillus niger species black aspergilli common
    • fungal extract
    • secondary metabolite
    • yanuthone D antibacterial-drug, antiinfective-drug synthesis
    • 00520, General biology - Symposia, transactions and proceedings
    • 12512, Pathology - Therapy
    • 22002, Pharmacology - General
    • 38502, Chemotherapy - General, methods and metabolism
    • 38504, Chemotherapy - Antibacterial agents
    • 39008, Food microbiology - General and miscellaneous
    • sclerotium induction method laboratory techniques
    • UHPLC-DAD-HRMS laboratory techniques, spectrum analysis techniques, chromatographic techniques
    • Bioprocess Engineering
    • Pharmacology

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