Unraveling cryptic chemistry in black aspergilli

Lene Maj Petersen; Jens Christian Frisvad; Thomas Ostenfeld Larsen

doi:10.1055/s-0034-1382347

Unraveling cryptic chemistry in black aspergilli

Lene Maj Petersen, Jens Christian Frisvad, Thomas Ostenfeld Larsen

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Abstract

The black aspergilli constitute an important group of species, both for their use in the biotechnological industry, and since they account for some of the most widespread food and feed contaminants. Most recently we have characterized the full biosynthetic pathway of the antibiotic yanuthone D from the industrially workhorse Aspergillus niger.1 On top of that we have presented a method for sclerotium induction, whereby we have reported sclerotia formation for the first time in seven black aspergilli, including A. niger.2 Thorough investigation by UHPLC-DAD-HRMS of fungal extracts, with and without sclerotia formation, have revealed a highly regulated metabolic profile for a number of species. We present this as an approach for the discovery of novel secondary metabolites from otherwise silent pathways.

Original language	English
Journal	Planta Medica
Volume	80
Issue number	10
ISSN	0032-0943
DOIs	https://doi.org/10.1055/s-0034-1382347
Publication status	Published - 2014
Event	American Society of Pharmacognosy 2014 Annual Meeting - Oxford, Mississippi, United States Duration: 2 Aug 2014 → 6 Oct 2014

Conference

Conference	American Society of Pharmacognosy 2014 Annual Meeting
Country/Territory	United States
City	Oxford, Mississippi
Period	02/08/2014 → 06/10/2014

Keywords

biotechnological industry
sclerotia formation
unraveling cryptic chemistry
Fungi Plantae (Fungi, Microorganisms, Nonvascular Plants, Plants) - Fungi Imperfecti or Deuteromycetes [15500] Aspergillus niger species black aspergilli common
fungal extract
secondary metabolite
yanuthone D antibacterial-drug, antiinfective-drug synthesis
00520, General biology - Symposia, transactions and proceedings
12512, Pathology - Therapy
22002, Pharmacology - General
38502, Chemotherapy - General, methods and metabolism
38504, Chemotherapy - Antibacterial agents
39008, Food microbiology - General and miscellaneous
sclerotium induction method laboratory techniques
UHPLC-DAD-HRMS laboratory techniques, spectrum analysis techniques, chromatographic techniques
Bioprocess Engineering
Pharmacology

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title = "Unraveling cryptic chemistry in black aspergilli",

abstract = "The black aspergilli constitute an important group of species, both for their use in the biotechnological industry, and since they account for some of the most widespread food and feed contaminants. Most recently we have characterized the full biosynthetic pathway of the antibiotic yanuthone D from the industrially workhorse Aspergillus niger.1 On top of that we have presented a method for sclerotium induction, whereby we have reported sclerotia formation for the first time in seven black aspergilli, including A. niger.2 Thorough investigation by UHPLC-DAD-HRMS of fungal extracts, with and without sclerotia formation, have revealed a highly regulated metabolic profile for a number of species. We present this as an approach for the discovery of novel secondary metabolites from otherwise silent pathways.",

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author = "Petersen, {Lene Maj} and Frisvad, {Jens Christian} and Larsen, {Thomas Ostenfeld}",

year = "2014",

doi = "10.1055/s-0034-1382347",

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journal = "Planta Medica",

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AU - Frisvad, Jens Christian

AU - Larsen, Thomas Ostenfeld

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N2 - The black aspergilli constitute an important group of species, both for their use in the biotechnological industry, and since they account for some of the most widespread food and feed contaminants. Most recently we have characterized the full biosynthetic pathway of the antibiotic yanuthone D from the industrially workhorse Aspergillus niger.1 On top of that we have presented a method for sclerotium induction, whereby we have reported sclerotia formation for the first time in seven black aspergilli, including A. niger.2 Thorough investigation by UHPLC-DAD-HRMS of fungal extracts, with and without sclerotia formation, have revealed a highly regulated metabolic profile for a number of species. We present this as an approach for the discovery of novel secondary metabolites from otherwise silent pathways.

AB - The black aspergilli constitute an important group of species, both for their use in the biotechnological industry, and since they account for some of the most widespread food and feed contaminants. Most recently we have characterized the full biosynthetic pathway of the antibiotic yanuthone D from the industrially workhorse Aspergillus niger.1 On top of that we have presented a method for sclerotium induction, whereby we have reported sclerotia formation for the first time in seven black aspergilli, including A. niger.2 Thorough investigation by UHPLC-DAD-HRMS of fungal extracts, with and without sclerotia formation, have revealed a highly regulated metabolic profile for a number of species. We present this as an approach for the discovery of novel secondary metabolites from otherwise silent pathways.

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KW - sclerotia formation

KW - unraveling cryptic chemistry

KW - Fungi Plantae (Fungi, Microorganisms, Nonvascular Plants, Plants) - Fungi Imperfecti or Deuteromycetes [15500] Aspergillus niger species black aspergilli common

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KW - secondary metabolite

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KW - Pharmacology

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DO - 10.1055/s-0034-1382347

M3 - Conference abstract in journal

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JO - Planta Medica

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IS - 10

T2 - American Society of Pharmacognosy 2014 Annual Meeting

Y2 - 2 August 2014 through 6 October 2014

ER -

Unraveling cryptic chemistry in black aspergilli

Abstract

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Keywords

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