Unnatural cyclodextrins can be accessed from enzyme-mediated dynamic combinatorial libraries

Dennis Larsen*, Michel Ferreira, Sébastien Tilloy, Eric Monflier, Sophie R. Beeren

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Dynamic systems of cyclodextrins (CDs) enabled by a native cyclodextrin glucanotransferase (CGTase) can incorporate unnatural glucopyranose-derived building blocks, expanding the applicability of enzyme-mediated dynamic combinatorial chemistry by using synthetically modified substrates. Starting dynamic combinatorial libraries from CDs with a single 6-modified glucopyranose results in a dynamic mixture of CDs containing several modified glucopyranoses. The relative concentrations of modified α, β or γ-CDs can be controlled by the addition of templates, providing a novel way to access modified CDs.
Original languageEnglish
JournalChemical Communications
Volume58
Issue number14
Pages (from-to)2287-2290
Number of pages4
ISSN1359-7345
DOIs
Publication statusPublished - 2022

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