Understanding cardiac extracellular matrix remodeling to develop biomarkers of myocardial infarction outcomes

Signe Holm Nielsen, Alan J. Mouton, Kristine Y. DeLeon-Pennell, Federica Genovese, Morten Asser Karsdal, Merry L. Lindsey*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

248 Downloads (Pure)

Abstract

Cardiovascular Disease (CVD) is the most common cause of death in industrialized countries, and myocardial infarction (MI) is a major CVD with significant morbidity and mortality. Following MI, the left ventricle (LV) undergoes a wound healing response to ischemia that results in extracellular matrix (ECM) scar formation to replace necrotic myocytes. While ECM accumulation following MI is termed cardiac fibrosis, this is a generic term that does not differentiate between ECM accumulation that occurs in the infarct region to form a scar that is structurally necessary to preserve left ventricle (LV) wall integrity and ECM accumulation that increases LV wall stiffness to exacerbate dilation and stimulate the progression to heart failure. This review focuses on post-MI LV ECM remodeling, targeting the discussion on ECM biomarkers that could be useful for predicting MI outcomes
Original languageEnglish
JournalMatrix Biology
Volume75-76
Pages (from-to)43-57
Number of pages15
ISSN0945-053X
DOIs
Publication statusPublished - 2019

Keywords

  • Extracellular matrix
  • Myocardinal infarction
  • Biomarkers
  • Collagen
  • Matrix metalloproteinases

Fingerprint Dive into the research topics of 'Understanding cardiac extracellular matrix remodeling to develop biomarkers of myocardial infarction outcomes'. Together they form a unique fingerprint.

Cite this