Uncoupling of vasopressin signaling in collecting ducts from rats with CBL-induced liver cirrhosis

Lone Brønd, Niels Hadrup, Nanna Salling, Malene Torp, Martin Graebe, Sten Christensen, Søren Nielsen, Thomas E. N. Jonassen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Vasopressin (AVP) stimulates collecting duct water reabsorption through cAMP-mediated membrane targeting and increased expression of the aquaporin-2 (AQP2) water channel. Rats with liver cirrhosis induced by common bile duct ligation (CBL) show decreased protein expression of AQP2 despite increased plasma concentrations of AVP. The present study was conducted to investigate possible mechanisms behind this uncoupling of AVP signaling. The rats were examined 4 wk after CBL or sham operation. The CBL rats had increased plasma AVP concentrations (CBL: 3.2+/-0.2 vs. sham: 1.4+/-0.4 pg/ml, P
Original languageEnglish
JournalAmerican Journal of Physiology: Renal Physiology
Volume287
Issue number4
Pages (from-to)F806-F815
ISSN1931-857X
DOIs
Publication statusPublished - 2004
Externally publishedYes

Cite this

Brønd, L., Hadrup, N., Salling, N., Torp, M., Graebe, M., Christensen, S., Nielsen, S., & Jonassen, T. E. N. (2004). Uncoupling of vasopressin signaling in collecting ducts from rats with CBL-induced liver cirrhosis. American Journal of Physiology: Renal Physiology, 287(4), F806-F815. https://doi.org/10.1152/ajprenal.00278.2003