Uncoupling of vasopressin signaling in collecting ducts from rats with CBL-induced liver cirrhosis

Lone Brønd; Niels Hadrup; Nanna Salling; Malene Torp; Martin Graebe; Sten Christensen; Søren Nielsen; Thomas E. N. Jonassen

doi:10.1152/ajprenal.00278.2003

Uncoupling of vasopressin signaling in collecting ducts from rats with CBL-induced liver cirrhosis

Lone Brønd, Niels Hadrup, Nanna Salling, Malene Torp, Martin Graebe, Sten Christensen, Søren Nielsen, Thomas E. N. Jonassen

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Vasopressin (AVP) stimulates collecting duct water reabsorption through cAMP-mediated membrane targeting and increased expression of the aquaporin-2 (AQP2) water channel. Rats with liver cirrhosis induced by common bile duct ligation (CBL) show decreased protein expression of AQP2 despite increased plasma concentrations of AVP. The present study was conducted to investigate possible mechanisms behind this uncoupling of AVP signaling. The rats were examined 4 wk after CBL or sham operation. The CBL rats had increased plasma AVP concentrations (CBL: 3.2+/-0.2 vs. sham: 1.4+/-0.4 pg/ml, P

Original language	English
Journal	American Journal of Physiology: Renal Physiology
Volume	287
Issue number	4
Pages (from-to)	F806-F815
ISSN	1931-857X
DOIs	https://doi.org/10.1152/ajprenal.00278.2003
Publication status	Published - 2004
Externally published	Yes

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title = "Uncoupling of vasopressin signaling in collecting ducts from rats with CBL-induced liver cirrhosis",

abstract = "Vasopressin (AVP) stimulates collecting duct water reabsorption through cAMP-mediated membrane targeting and increased expression of the aquaporin-2 (AQP2) water channel. Rats with liver cirrhosis induced by common bile duct ligation (CBL) show decreased protein expression of AQP2 despite increased plasma concentrations of AVP. The present study was conducted to investigate possible mechanisms behind this uncoupling of AVP signaling. The rats were examined 4 wk after CBL or sham operation. The CBL rats had increased plasma AVP concentrations (CBL: 3.2+/-0.2 vs. sham: 1.4+/-0.4 pg/ml, P",

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T1 - Uncoupling of vasopressin signaling in collecting ducts from rats with CBL-induced liver cirrhosis

AU - Brønd, Lone

AU - Hadrup, Niels

AU - Salling, Nanna

AU - Torp, Malene

AU - Graebe, Martin

AU - Christensen, Sten

AU - Nielsen, Søren

AU - Jonassen, Thomas E. N.

PY - 2004

Y1 - 2004

N2 - Vasopressin (AVP) stimulates collecting duct water reabsorption through cAMP-mediated membrane targeting and increased expression of the aquaporin-2 (AQP2) water channel. Rats with liver cirrhosis induced by common bile duct ligation (CBL) show decreased protein expression of AQP2 despite increased plasma concentrations of AVP. The present study was conducted to investigate possible mechanisms behind this uncoupling of AVP signaling. The rats were examined 4 wk after CBL or sham operation. The CBL rats had increased plasma AVP concentrations (CBL: 3.2+/-0.2 vs. sham: 1.4+/-0.4 pg/ml, P

AB - Vasopressin (AVP) stimulates collecting duct water reabsorption through cAMP-mediated membrane targeting and increased expression of the aquaporin-2 (AQP2) water channel. Rats with liver cirrhosis induced by common bile duct ligation (CBL) show decreased protein expression of AQP2 despite increased plasma concentrations of AVP. The present study was conducted to investigate possible mechanisms behind this uncoupling of AVP signaling. The rats were examined 4 wk after CBL or sham operation. The CBL rats had increased plasma AVP concentrations (CBL: 3.2+/-0.2 vs. sham: 1.4+/-0.4 pg/ml, P

U2 - 10.1152/ajprenal.00278.2003

DO - 10.1152/ajprenal.00278.2003

M3 - Journal article

SN - 1931-857X

VL - 287

SP - F806-F815

JO - American Journal of Physiology: Renal Physiology

JF - American Journal of Physiology: Renal Physiology

IS - 4

ER -

Uncoupling of vasopressin signaling in collecting ducts from rats with CBL-induced liver cirrhosis

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