Ultra-high field MR angiography in human migraine models: a 3.0T/7.0T comparison study

Casper Emil Christensen, Samaira Younis, Ulrich Lindberg, Vincent Oltman Boer, Patrick de Koning, Esben Thade Petersen, Olaf Bjarne Paulson, Henrik Bo Wiberg Larsson, Faisal Mohammad Amin, Messoud Ashina*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Background: Sildenafil and calcitonin gene-related peptide both dilate the intradural segments of the middle meningeal artery measured with 3.0 tesla (T) MR angiography. Here we hypothesized that an increase in field strength to 7.0T and concomitant enhanced voxel resolution would lower variance in measurements of dilation in the intradural middle meningeal artery. 
Methods: Five subjects completed two sessions at respectively 3.0T and 7.0T. Each session comprised MR angiography scans once before and twice after administration of sildenafil, calcitonin gene-related peptide or placebo in a three-way, crossover, double-blind, placebo-controlled design. 
Results: Standard deviations of arterial circumference revealed no difference between 3.0T and 7.0T measurements (p=0.379). We found a decrease in standard deviation from our original angiography analysis software (QMra) to a newer (LAVA) software package (p= 0.379). We found a decrease in standard deviation from our original angiography analysissoftware (QMra) to a newer (LAVA) software package (p < 0.001). Furthermore, we found that the dilation aftersildenafil and calcitonin gene-related peptide were comparable between 3.0 T and 7.0 T. 
Conclusions: Our findings suggest no gain from the increase in voxel resolution but cemented dilatory findingsfrom earlier. The implemented software update improved variance in circumference measurements in the intraduralmiddle meningeal artery, which should be exploited in future studies.
Original languageEnglish
Article number48
JournalThe Journal of Headache and Pain
Volume20
Issue number1
Number of pages7
ISSN1129-2369
DOIs
Publication statusPublished - 2019

Keywords

  • Middle meningeal artery
  • Dura mater
  • Neurovascular
  • Sildenafil
  • Calcitonin gene-related peptide

Cite this

Christensen, Casper Emil ; Younis, Samaira ; Lindberg, Ulrich ; Boer, Vincent Oltman ; de Koning, Patrick ; Petersen, Esben Thade ; Paulson, Olaf Bjarne ; Larsson, Henrik Bo Wiberg ; Amin, Faisal Mohammad ; Ashina, Messoud. / Ultra-high field MR angiography in human migraine models: a 3.0T/7.0T comparison study. In: The Journal of Headache and Pain. 2019 ; Vol. 20, No. 1.
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title = "Ultra-high field MR angiography in human migraine models: a 3.0T/7.0T comparison study",
abstract = "Background: Sildenafil and calcitonin gene-related peptide both dilate the intradural segments of the middle meningeal artery measured with 3.0 tesla (T) MR angiography. Here we hypothesized that an increase in field strength to 7.0T and concomitant enhanced voxel resolution would lower variance in measurements of dilation in the intradural middle meningeal artery. Methods: Five subjects completed two sessions at respectively 3.0T and 7.0T. Each session comprised MR angiography scans once before and twice after administration of sildenafil, calcitonin gene-related peptide or placebo in a three-way, crossover, double-blind, placebo-controlled design. Results: Standard deviations of arterial circumference revealed no difference between 3.0T and 7.0T measurements (p=0.379). We found a decrease in standard deviation from our original angiography analysis software (QMra) to a newer (LAVA) software package (p= 0.379). We found a decrease in standard deviation from our original angiography analysissoftware (QMra) to a newer (LAVA) software package (p < 0.001). Furthermore, we found that the dilation aftersildenafil and calcitonin gene-related peptide were comparable between 3.0 T and 7.0 T. Conclusions: Our findings suggest no gain from the increase in voxel resolution but cemented dilatory findingsfrom earlier. The implemented software update improved variance in circumference measurements in the intraduralmiddle meningeal artery, which should be exploited in future studies.",
keywords = "Middle meningeal artery, Dura mater, Neurovascular, Sildenafil, Calcitonin gene-related peptide",
author = "Christensen, {Casper Emil} and Samaira Younis and Ulrich Lindberg and Boer, {Vincent Oltman} and {de Koning}, Patrick and Petersen, {Esben Thade} and Paulson, {Olaf Bjarne} and Larsson, {Henrik Bo Wiberg} and Amin, {Faisal Mohammad} and Messoud Ashina",
year = "2019",
doi = "10.1186/s10194-019-0996-x",
language = "English",
volume = "20",
journal = "The Journal of Headache and Pain",
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Christensen, CE, Younis, S, Lindberg, U, Boer, VO, de Koning, P, Petersen, ET, Paulson, OB, Larsson, HBW, Amin, FM & Ashina, M 2019, 'Ultra-high field MR angiography in human migraine models: a 3.0T/7.0T comparison study', The Journal of Headache and Pain, vol. 20, no. 1, 48. https://doi.org/10.1186/s10194-019-0996-x

Ultra-high field MR angiography in human migraine models: a 3.0T/7.0T comparison study. / Christensen, Casper Emil; Younis, Samaira; Lindberg, Ulrich; Boer, Vincent Oltman; de Koning, Patrick; Petersen, Esben Thade; Paulson, Olaf Bjarne; Larsson, Henrik Bo Wiberg; Amin, Faisal Mohammad; Ashina, Messoud.

In: The Journal of Headache and Pain, Vol. 20, No. 1, 48, 2019.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Ultra-high field MR angiography in human migraine models: a 3.0T/7.0T comparison study

AU - Christensen, Casper Emil

AU - Younis, Samaira

AU - Lindberg, Ulrich

AU - Boer, Vincent Oltman

AU - de Koning, Patrick

AU - Petersen, Esben Thade

AU - Paulson, Olaf Bjarne

AU - Larsson, Henrik Bo Wiberg

AU - Amin, Faisal Mohammad

AU - Ashina, Messoud

PY - 2019

Y1 - 2019

N2 - Background: Sildenafil and calcitonin gene-related peptide both dilate the intradural segments of the middle meningeal artery measured with 3.0 tesla (T) MR angiography. Here we hypothesized that an increase in field strength to 7.0T and concomitant enhanced voxel resolution would lower variance in measurements of dilation in the intradural middle meningeal artery. Methods: Five subjects completed two sessions at respectively 3.0T and 7.0T. Each session comprised MR angiography scans once before and twice after administration of sildenafil, calcitonin gene-related peptide or placebo in a three-way, crossover, double-blind, placebo-controlled design. Results: Standard deviations of arterial circumference revealed no difference between 3.0T and 7.0T measurements (p=0.379). We found a decrease in standard deviation from our original angiography analysis software (QMra) to a newer (LAVA) software package (p= 0.379). We found a decrease in standard deviation from our original angiography analysissoftware (QMra) to a newer (LAVA) software package (p < 0.001). Furthermore, we found that the dilation aftersildenafil and calcitonin gene-related peptide were comparable between 3.0 T and 7.0 T. Conclusions: Our findings suggest no gain from the increase in voxel resolution but cemented dilatory findingsfrom earlier. The implemented software update improved variance in circumference measurements in the intraduralmiddle meningeal artery, which should be exploited in future studies.

AB - Background: Sildenafil and calcitonin gene-related peptide both dilate the intradural segments of the middle meningeal artery measured with 3.0 tesla (T) MR angiography. Here we hypothesized that an increase in field strength to 7.0T and concomitant enhanced voxel resolution would lower variance in measurements of dilation in the intradural middle meningeal artery. Methods: Five subjects completed two sessions at respectively 3.0T and 7.0T. Each session comprised MR angiography scans once before and twice after administration of sildenafil, calcitonin gene-related peptide or placebo in a three-way, crossover, double-blind, placebo-controlled design. Results: Standard deviations of arterial circumference revealed no difference between 3.0T and 7.0T measurements (p=0.379). We found a decrease in standard deviation from our original angiography analysis software (QMra) to a newer (LAVA) software package (p= 0.379). We found a decrease in standard deviation from our original angiography analysissoftware (QMra) to a newer (LAVA) software package (p < 0.001). Furthermore, we found that the dilation aftersildenafil and calcitonin gene-related peptide were comparable between 3.0 T and 7.0 T. Conclusions: Our findings suggest no gain from the increase in voxel resolution but cemented dilatory findingsfrom earlier. The implemented software update improved variance in circumference measurements in the intraduralmiddle meningeal artery, which should be exploited in future studies.

KW - Middle meningeal artery

KW - Dura mater

KW - Neurovascular

KW - Sildenafil

KW - Calcitonin gene-related peptide

U2 - 10.1186/s10194-019-0996-x

DO - 10.1186/s10194-019-0996-x

M3 - Journal article

VL - 20

JO - The Journal of Headache and Pain

JF - The Journal of Headache and Pain

SN - 1129-2369

IS - 1

M1 - 48

ER -