TY - JOUR
T1 - Ultra-high field MR angiography in human migraine models: a 3.0T/7.0T comparison study
AU - Christensen, Casper Emil
AU - Younis, Samaira
AU - Lindberg, Ulrich
AU - Boer, Vincent Oltman
AU - de Koning, Patrick
AU - Petersen, Esben Thade
AU - Paulson, Olaf Bjarne
AU - Larsson, Henrik Bo Wiberg
AU - Amin, Faisal Mohammad
AU - Ashina, Messoud
PY - 2019
Y1 - 2019
N2 - Background: Sildenafil and calcitonin gene-related peptide both dilate the intradural segments of the middle meningeal artery measured with 3.0 tesla (T) MR angiography. Here we hypothesized that an increase in field strength to 7.0T and concomitant enhanced voxel resolution would lower variance in measurements of dilation in the intradural middle meningeal artery. Methods: Five subjects completed two sessions at respectively 3.0T and 7.0T. Each session comprised MR angiography scans once before and twice after administration of sildenafil, calcitonin gene-related peptide or placebo in a three-way, crossover, double-blind, placebo-controlled design. Results: Standard deviations of arterial circumference revealed no difference between 3.0T and 7.0T measurements (p=0.379). We found a decrease in standard deviation from our original angiography analysis software (QMra) to a newer (LAVA) software package (p= 0.379). We found a decrease in standard deviation from our original angiography analysissoftware (QMra) to a newer (LAVA) software package (p < 0.001). Furthermore, we found that the dilation aftersildenafil and calcitonin gene-related peptide were comparable between 3.0 T and 7.0 T. Conclusions: Our findings suggest no gain from the increase in voxel resolution but cemented dilatory findingsfrom earlier. The implemented software update improved variance in circumference measurements in the intraduralmiddle meningeal artery, which should be exploited in future studies.
AB - Background: Sildenafil and calcitonin gene-related peptide both dilate the intradural segments of the middle meningeal artery measured with 3.0 tesla (T) MR angiography. Here we hypothesized that an increase in field strength to 7.0T and concomitant enhanced voxel resolution would lower variance in measurements of dilation in the intradural middle meningeal artery. Methods: Five subjects completed two sessions at respectively 3.0T and 7.0T. Each session comprised MR angiography scans once before and twice after administration of sildenafil, calcitonin gene-related peptide or placebo in a three-way, crossover, double-blind, placebo-controlled design. Results: Standard deviations of arterial circumference revealed no difference between 3.0T and 7.0T measurements (p=0.379). We found a decrease in standard deviation from our original angiography analysis software (QMra) to a newer (LAVA) software package (p= 0.379). We found a decrease in standard deviation from our original angiography analysissoftware (QMra) to a newer (LAVA) software package (p < 0.001). Furthermore, we found that the dilation aftersildenafil and calcitonin gene-related peptide were comparable between 3.0 T and 7.0 T. Conclusions: Our findings suggest no gain from the increase in voxel resolution but cemented dilatory findingsfrom earlier. The implemented software update improved variance in circumference measurements in the intraduralmiddle meningeal artery, which should be exploited in future studies.
KW - Middle meningeal artery
KW - Dura mater
KW - Neurovascular
KW - Sildenafil
KW - Calcitonin gene-related peptide
U2 - 10.1186/s10194-019-0996-x
DO - 10.1186/s10194-019-0996-x
M3 - Journal article
C2 - 31060491
SN - 1129-2369
VL - 20
JO - The Journal of Headache and Pain
JF - The Journal of Headache and Pain
IS - 1
M1 - 48
ER -