Ultra-high field MR angiography in human migraine models: a 3.0T/7.0T comparison study

Casper Emil Christensen, Samaira Younis, Ulrich Lindberg, Vincent Oltman Boer, Patrick de Koning, Esben Thade Petersen, Olaf Bjarne Paulson, Henrik Bo Wiberg Larsson, Faisal Mohammad Amin, Messoud Ashina*

*Corresponding author for this work

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Background: Sildenafil and calcitonin gene-related peptide both dilate the intradural segments of the middle meningeal artery measured with 3.0 tesla (T) MR angiography. Here we hypothesized that an increase in field strength to 7.0T and concomitant enhanced voxel resolution would lower variance in measurements of dilation in the intradural middle meningeal artery. 
Methods: Five subjects completed two sessions at respectively 3.0T and 7.0T. Each session comprised MR angiography scans once before and twice after administration of sildenafil, calcitonin gene-related peptide or placebo in a three-way, crossover, double-blind, placebo-controlled design. 
Results: Standard deviations of arterial circumference revealed no difference between 3.0T and 7.0T measurements (p=0.379). We found a decrease in standard deviation from our original angiography analysis software (QMra) to a newer (LAVA) software package (p= 0.379). We found a decrease in standard deviation from our original angiography analysissoftware (QMra) to a newer (LAVA) software package (p < 0.001). Furthermore, we found that the dilation aftersildenafil and calcitonin gene-related peptide were comparable between 3.0 T and 7.0 T. 
Conclusions: Our findings suggest no gain from the increase in voxel resolution but cemented dilatory findingsfrom earlier. The implemented software update improved variance in circumference measurements in the intraduralmiddle meningeal artery, which should be exploited in future studies.
Original languageEnglish
Article number48
JournalThe Journal of Headache and Pain
Issue number1
Number of pages7
Publication statusPublished - 2019


  • Middle meningeal artery
  • Dura mater
  • Neurovascular
  • Sildenafil
  • Calcitonin gene-related peptide

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