Type XXIV collagen

S. Holm Nielsen; M. Crespo-Bravo; M. A. Karsdal

doi:10.1016/B978-0-443-15617-5.00006-8

Type XXIV collagen

S. Holm Nielsen, M. Crespo-Bravo, M. A. Karsdal

Department of Biotechnology and Biomedicine

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Abstract

Type XXIV collagen is a fibrillar collagen containing two collagenous domains and three noncollagenous domains. The amino-terminal peptide contains a thrombospodin-N-terminal-like motif and a highly charged segment interspersed with several tyrosine residues. Type XXIV collagen is predominately expressed in the formation of bone but to a lesser extent is also found in soft tissues such as the brain, muscle, kidneys, spleen, liver, lung, testis, and ovary. The gene COL24A1 is increased during squamous cell carcinoma of the head and neck could be a marker of osteoblast differentiation and certain types of cancers. Currently, there are no mutations in humans or mice associated with biological functions, and no biomarkers have been put forward.

Original language	English
Title of host publication	Biochemistry of Collagens, Laminins and Elastin : Structure, Function and Biomarkers
Editors	Morten A. Karsdal
Number of pages	3
Publisher	Elsevier
Publication date	2024
Edition	3rd
Pages	203-205
Chapter	24
ISBN (Electronic)	978-0-443-15617-5
DOIs	https://doi.org/10.1016/B978-0-443-15617-5.00006-8
Publication status	Published - 2024

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title = "Type XXIV collagen",

abstract = "Type XXIV collagen is a fibrillar collagen containing two collagenous domains and three noncollagenous domains. The amino-terminal peptide contains a thrombospodin-N-terminal-like motif and a highly charged segment interspersed with several tyrosine residues. Type XXIV collagen is predominately expressed in the formation of bone but to a lesser extent is also found in soft tissues such as the brain, muscle, kidneys, spleen, liver, lung, testis, and ovary. The gene COL24A1 is increased during squamous cell carcinoma of the head and neck could be a marker of osteoblast differentiation and certain types of cancers. Currently, there are no mutations in humans or mice associated with biological functions, and no biomarkers have been put forward.",

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AU - Holm Nielsen, S.

AU - Crespo-Bravo, M.

AU - Karsdal, M. A.

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N2 - Type XXIV collagen is a fibrillar collagen containing two collagenous domains and three noncollagenous domains. The amino-terminal peptide contains a thrombospodin-N-terminal-like motif and a highly charged segment interspersed with several tyrosine residues. Type XXIV collagen is predominately expressed in the formation of bone but to a lesser extent is also found in soft tissues such as the brain, muscle, kidneys, spleen, liver, lung, testis, and ovary. The gene COL24A1 is increased during squamous cell carcinoma of the head and neck could be a marker of osteoblast differentiation and certain types of cancers. Currently, there are no mutations in humans or mice associated with biological functions, and no biomarkers have been put forward.

AB - Type XXIV collagen is a fibrillar collagen containing two collagenous domains and three noncollagenous domains. The amino-terminal peptide contains a thrombospodin-N-terminal-like motif and a highly charged segment interspersed with several tyrosine residues. Type XXIV collagen is predominately expressed in the formation of bone but to a lesser extent is also found in soft tissues such as the brain, muscle, kidneys, spleen, liver, lung, testis, and ovary. The gene COL24A1 is increased during squamous cell carcinoma of the head and neck could be a marker of osteoblast differentiation and certain types of cancers. Currently, there are no mutations in humans or mice associated with biological functions, and no biomarkers have been put forward.

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DO - 10.1016/B978-0-443-15617-5.00006-8

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BT - Biochemistry of Collagens, Laminins and Elastin

A2 - Karsdal, Morten A.

PB - Elsevier

ER -

Type XXIV collagen

Abstract

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