Type XXIV collagen is a fibrillar collagen containing two collagenous domains and three noncollagenous domains. The amino-terminal peptide contains a thrombospondin N-terminal–like motif and a highly charged segment interspersed with several tyrosine residues. Type XXIV collagen is predominately expressed in the formation of bone; however, it has recently been found in the brain, muscle, kidney, spleen, liver, lung, testis, and ovary, but to a far lesser extent than in bone. COL24A1 is increased during squamous cell carcinoma of the head and neck and could be a marker of osteoblast differentiation and certain types of cancers. Currently there are no mutations in humans or mice associated with biological functions, and no biomarkers have been put forward.
|Title of host publication||Biochemistry of Collagens, Laminins and Elastin : Structure, Function and Biomarkers|
|Publication status||Published - 2016|