Type XXIV Collagen

Signe Holm Nielsen, Morten Asser Karsdal

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review


Type XXIV collagen is a fibrillar collagen containing two collagenous domains and three noncollagenous domains. The amino-terminal peptide contains a thrombospondin N-terminal–like motif and a highly charged segment interspersed with several tyrosine residues. Type XXIV collagen is predominately expressed in the formation of bone; however, it has recently been found in the brain, muscle, kidney, spleen, liver, lung, testis, and ovary, but to a far lesser extent than in bone. COL24A1 is increased during squamous cell carcinoma of the head and neck and could be a marker of osteoblast differentiation and certain types of cancers. Currently there are no mutations in humans or mice associated with biological functions, and no biomarkers have been put forward.
Original languageEnglish
Title of host publicationBiochemistry of Collagens, Laminins and Elastin : Structure, Function and Biomarkers
Publication date2016
ISBN (Print)978-0-12-809847-9
Publication statusPublished - 2016
Externally publishedYes

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