Tunable Ampere phase plate for low dose imaging of biomolecular complexes

Amir H. Tavabi*, Marco Beleggia, Vadim Migunov, Alexey Savenko, Ozan Öktem, Rafal E. Dunin-Borkowski, Giulio Pozzi

*Corresponding author for this work

    Research output: Contribution to journalJournal articleResearchpeer-review

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    A novel device that can be used as a tunable support-free phase plate for transmission electron microscopy of weakly scattering specimens is described. The device relies on the generation of a controlled phase shift by the magnetic field of a segment of current-carrying wire that is oriented parallel or antiparallel to the electron beam. The validity of the concept is established using both experimental electron holographic measurements and a theoretical model based on Ampere's law. Computer simulations are used to illustrate the resulting contrast enhancement for studies of biological cells and macromolecules.
    Original languageEnglish
    Article number5592
    JournalScientific Reports
    Issue number1
    Number of pages5
    Publication statusPublished - 2018

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