Tritium labelling of PACAP-38 using a synthetic diiodinated precursor peptide

Martin Holst Friborg Pedersen, Michael Baun

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    In the interest of developing efficient methods for tritium labelling peptides, we here demonstrate the successful labelling of PACAP-38 (pituitary adenylate cyclase-activating polypeptide), a 38-mer peptide, using a synthetic diiodinated PACAP-38 precursor. In this example, we employ standard hydrogenation chemistry with the use of a heterogeneous palladium catalyst and carrier-free tritium gas on a tritium manifold system.
    Original languageEnglish
    JournalJournal of Labelled Compounds and Radiopharmaceuticals
    Volume55
    Issue number1
    Pages (from-to)1-4
    ISSN0362-4803
    DOIs
    Publication statusPublished - 2012

    Keywords

    • PACAP
    • Tritium
    • Heterogeneous catalysis
    • Headache
    • Tritiodeiodination
    • Peptide

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