TY - JOUR
T1 - Trichomonas vaginalis surface proteins: a view from the genome
AU - Hirt, R. P.
AU - Noel, C. J.
AU - Sicheritz-Pontén, Thomas
AU - Tachezy, J.
AU - Fiori, P. L.
PY - 2007
Y1 - 2007
N2 - Surface proteins of mucosal microbial pathogens play multiple and essential roles in initiating and sustaining the colonization of the heavily defended mucosa. The protist Trichomonas vaginalis is one of the most common human sexually transmitted pathogens that colonize the urogenital mucosa. However, little is known about its surface proteins. The recently completed draft genome sequence of T. vaginalis provides an invaluable resource to guide molecular and cellular characterization of surface proteins and to investigate their role in pathogenicity. Here, we review the existing data on T. vaginalis surface proteins and summarize some of the main findings from the recent in silico characterization of its candidate surface proteins.
AB - Surface proteins of mucosal microbial pathogens play multiple and essential roles in initiating and sustaining the colonization of the heavily defended mucosa. The protist Trichomonas vaginalis is one of the most common human sexually transmitted pathogens that colonize the urogenital mucosa. However, little is known about its surface proteins. The recently completed draft genome sequence of T. vaginalis provides an invaluable resource to guide molecular and cellular characterization of surface proteins and to investigate their role in pathogenicity. Here, we review the existing data on T. vaginalis surface proteins and summarize some of the main findings from the recent in silico characterization of its candidate surface proteins.
U2 - 10.1016/j.pt.2007.08.020
DO - 10.1016/j.pt.2007.08.020
M3 - Journal article
SN - 1471-4922
VL - 23
SP - 540
EP - 547
JO - Trends in Parasitology
JF - Trends in Parasitology
IS - 11
ER -