Trends and clinico-epidemiological features of human rabies cases in Bangladesh 2006-2018

Sumon Ghosh*, Md Sohel Rana, Md Kamrul Islam, Sukanta Chowdhury, Najmul Haider, Mohammad Abdullah Heel Kafi, Sayed Mohammed Ullah, Md Rashed Ali Shah, Afsana Akter Jahan, Hasan Sayedul Mursalin, Aung Swi Prue Marma, S M Emran Ali, Shohrab Hossain, Rajub Bhowmik, Nitish C Debnath, Abul Khair Mohammad Shamsuzzaman, Be-Nazir Ahmed, Umme Ruman Siddiqi, Sanya Tahmina Jhora

*Corresponding author for this work

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Abstract

Vaccinating dogs against rabies is an effective means of reducing human rabies. We subjected 1327 clinically diagnosed human rabies death and mass dog vaccination (MDV) data during 2006–2018 to quantify the impacts of MDV on human rabies incidence in Bangladesh and a subset of rabies death data (422) for clinico-epidemiological analysis. A positive and increasing trend of MDV (p = 0.01 and tau = 0.71) and a negative and declining trend (p < 0.001 and tau = −0.88) of human rabies cases (Correlation coefficient: −0.82) have been observed. Among 422 deaths, the majority (78%) of the victims sought treatment from traditional healers, and 12% received post-exposure prophylaxis (PEP). The mean incubation period of rabies in cases with exposure sites on the head & neck (35 days) was shorter than the upper limb (mean = 64 days, p = 0.02) and lower limb (mean = 89 days, p < 0.01). MDV has been found to be effective for reducing human rabies cases in Bangladesh. Creating awareness among the animal bite victims to stop reliance on traditional healers rather seeking PEP, addressing the role of traditional healers through awareness education programme with respect to the treatment of dog bites, ensuring availability of PEP, and continuing to scale up MDV may help to prevent human rabies deaths.
Original languageEnglish
Article number2410
JournalScientific Reports
Volume10
Issue number1
Number of pages11
ISSN2045-2322
DOIs
Publication statusPublished - 2020

Cite this

Ghosh, S., Rana, M. S., Islam, M. K., Chowdhury, S., Haider, N., Kafi, M. A. H., Ullah, S. M., Shah, M. R. A., Jahan, A. A., Mursalin, H. S., Marma, A. S. P., Ali, S. M. E., Hossain, S., Bhowmik, R., Debnath, N. C., Shamsuzzaman, A. K. M., Ahmed, B-N., Siddiqi, U. R., & Jhora, S. T. (2020). Trends and clinico-epidemiological features of human rabies cases in Bangladesh 2006-2018. Scientific Reports, 10(1), [2410]. https://doi.org/10.1038/s41598-020-59109-w