Treatment with Anaerobutyricum soehngenii: a pilot study of safety and dose–response effects on glucose metabolism in human subjects with metabolic syndrome

Pim W. Gilijamse, Annick V. Hartstra, Evgeni Levin, Koen Wortelboer, Mireille J. Serlie, Mariette T. Ackermans, Hilde Herrema, Aart J. Nederveen, Sultan Imangaliyev, Steven Aalvink, Morton Sommer, Han Levels, Erik S.G. Stroes, Albert K. Groen, Marleen Kemper, Willem M. de Vos, Max Nieuwdorp, Andrei Prodan*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Dysbiosis of the intestinal microbiota has been implicated in insulin resistance, although evidence regarding causality in humans is scarce. We performed a phase I/II dose-finding and safety study on the effect of oral intake of the anaerobic butyrogenic strain Anaerobutyricum soehngenii on glucose metabolism in 24 subjects with metabolic syndrome. We found that treatment with A. soehngenii was safe and observed a significant correlation between the measured fecal abundance of administered A. soehngenii and improvement in peripheral insulin sensitivity after 4 weeks of treatment. This was accompanied by an altered microbiota composition and a change in bile acid metabolism. Finally, we show that metabolic response upon administration of A. soehngenii (defined as improved insulin sensitivity 4 weeks after A. soehngenii intake) is dependent on microbiota composition at baseline. These data in humans are promising, but additional studies are needed to reproduce our findings and to investigate long-term effects, as well as other modes of delivery.

Original languageEnglish
Article number16
JournalNPJ biofilms and microbiomes
Volume6
Issue number1
Number of pages19
ISSN2055-5008
DOIs
Publication statusPublished - 2020

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