Transthoracic Vector Flow Imaging in Pediatric Patients with Valvular Stenosis-A Proof of Concept Study

Tin Quoc Nguyen*, Thor Bechsgaard, Michael Rahbek Schmidt, Klaus Juul, Ramin Moshavegh, Lars Lönn, Michael Bachmann Nielsen, Jorgen Arendt Jensen, Kristoffer Lindskov Hansen

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review


Purpose Continuous wave Doppler ultrasound is routinely used to detect cardiac valve stenoses. Vector flow imaging (VFI) is an angle-independent real-time ultrasound method that can quantify flow complexity. We aimed to evaluate if quantification of flow complexity could reliably assess valvular stenosis in pediatric patients. Materials and Methods Nine pediatric patients with echocardiographically confirmed valvular stenosis were included in the study. VFI and Doppler measurements were compared with transvalvular peak-to-peak pressure differences derived from invasive endovascular catheterization. Results Vector concentration correlated with the catheter measurements before intervention after exclusion of one outlier (r=-0.83, p=0.01), whereas the Doppler method did not (r=0.49, p=0.22). The change in vector concentration after intervention correlated strongly with the change in the measured catheter pressure difference (r=-0.86, p=0.003), while Doppler showed a tendency for a moderate correlation (r=0.63, p=0.07). Conclusion Transthoracic flow complexity quantification calculated from VFI data is feasible and may be useful for assessing valvular stenosis severity in pediatric patients.

Original languageEnglish
JournalUltrasound International Open
Issue number2
Pages (from-to)E48-E54
Publication statusPublished - 2021


  • Catheters
  • Echocardiography
  • Vector flow Imaging
  • Valvular stenosis
  • Pressure gradient


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