Transmission of foot-and-mouth disease from persistently infected carrier cattle to naïve cattle via transfer of oropharyngeal fluid.

Research output: Contribution to journalJournal article – Annual report year: 2018Researchpeer-review

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Transmission of foot-and-mouth disease from persistently infected carrier cattle to naïve cattle via transfer of oropharyngeal fluid. / Arzt, Jonathan ; Belsham, Graham; Lohse, Louise; Bøtner, Anette; Stenfeldt, Carolina .

In: mSphere, Vol. 3, No. 5, 2018.

Research output: Contribution to journalJournal article – Annual report year: 2018Researchpeer-review

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@article{220beab637114e1e88173854acad33f9,
title = "Transmission of foot-and-mouth disease from persistently infected carrier cattle to na{\"i}ve cattle via transfer of oropharyngeal fluid.",
abstract = "Control and eradication of foot-and-mouth disease (FMD) is impeded by the existence of a persistent, subclinical, phase of infection in ruminants; animals with this status are referred to as carriers. However, the epidemiological significance of these FMD virus (FMDV) carriers isuncertain. In the current investigation, the contagion associated with FMDV carrier cattle was investigated by exposure of susceptible cattle and pigs to oropharyngeal fluid (OPF) or tissues harvested from persistently infected cattle. Na{\"i}ve cattle were inoculated through intranasopharyngeal deposition of unprocessed OPF that had been collected from FMDV carriers at 30 days post infection. These inoculated cattle developed clinical FMD of similar severity as animals that had been infected with a high-titer inoculum. In contrast, pigs exposed via intraoropharyngeal inoculation of the same OPF, or by ingestion of nasopharyngeal tissues harvested from the same cohort of persistently infected cattle, did not develop FMD. These findings indicate that there is demonstrable contagion associated with FMDV carrier cattle despite thelack of evidence for transmission by direct contact. The findings presented herein provide novel information that should be considered for FMD risk mitigation strategies.",
keywords = "FMDV, Carrier, Cow, Foot-and-mouth disease, Foot-and-mouth disease virus, Risk, Transmission , Virus",
author = "Jonathan Arzt and Graham Belsham and Louise Lohse and Anette B{\o}tner and Carolina Stenfeldt",
note = "This is a work of the U.S. Government and is not subject to copyright protection in the United States. Foreign copyrights may apply.",
year = "2018",
doi = "10.1128/mSphere.00365-18",
language = "English",
volume = "3",
journal = "mSphere",
issn = "1535-9786",
publisher = "American Society for Microbiology",
number = "5",

}

RIS

TY - JOUR

T1 - Transmission of foot-and-mouth disease from persistently infected carrier cattle to naïve cattle via transfer of oropharyngeal fluid.

AU - Arzt, Jonathan

AU - Belsham, Graham

AU - Lohse, Louise

AU - Bøtner, Anette

AU - Stenfeldt, Carolina

N1 - This is a work of the U.S. Government and is not subject to copyright protection in the United States. Foreign copyrights may apply.

PY - 2018

Y1 - 2018

N2 - Control and eradication of foot-and-mouth disease (FMD) is impeded by the existence of a persistent, subclinical, phase of infection in ruminants; animals with this status are referred to as carriers. However, the epidemiological significance of these FMD virus (FMDV) carriers isuncertain. In the current investigation, the contagion associated with FMDV carrier cattle was investigated by exposure of susceptible cattle and pigs to oropharyngeal fluid (OPF) or tissues harvested from persistently infected cattle. Naïve cattle were inoculated through intranasopharyngeal deposition of unprocessed OPF that had been collected from FMDV carriers at 30 days post infection. These inoculated cattle developed clinical FMD of similar severity as animals that had been infected with a high-titer inoculum. In contrast, pigs exposed via intraoropharyngeal inoculation of the same OPF, or by ingestion of nasopharyngeal tissues harvested from the same cohort of persistently infected cattle, did not develop FMD. These findings indicate that there is demonstrable contagion associated with FMDV carrier cattle despite thelack of evidence for transmission by direct contact. The findings presented herein provide novel information that should be considered for FMD risk mitigation strategies.

AB - Control and eradication of foot-and-mouth disease (FMD) is impeded by the existence of a persistent, subclinical, phase of infection in ruminants; animals with this status are referred to as carriers. However, the epidemiological significance of these FMD virus (FMDV) carriers isuncertain. In the current investigation, the contagion associated with FMDV carrier cattle was investigated by exposure of susceptible cattle and pigs to oropharyngeal fluid (OPF) or tissues harvested from persistently infected cattle. Naïve cattle were inoculated through intranasopharyngeal deposition of unprocessed OPF that had been collected from FMDV carriers at 30 days post infection. These inoculated cattle developed clinical FMD of similar severity as animals that had been infected with a high-titer inoculum. In contrast, pigs exposed via intraoropharyngeal inoculation of the same OPF, or by ingestion of nasopharyngeal tissues harvested from the same cohort of persistently infected cattle, did not develop FMD. These findings indicate that there is demonstrable contagion associated with FMDV carrier cattle despite thelack of evidence for transmission by direct contact. The findings presented herein provide novel information that should be considered for FMD risk mitigation strategies.

KW - FMDV

KW - Carrier

KW - Cow

KW - Foot-and-mouth disease

KW - Foot-and-mouth disease virus

KW - Risk

KW - Transmission

KW - Virus

U2 - 10.1128/mSphere.00365-18

DO - 10.1128/mSphere.00365-18

M3 - Journal article

VL - 3

JO - mSphere

JF - mSphere

SN - 1535-9786

IS - 5

ER -