Transmission of foot-and-mouth disease from persistently infected carrier cattle to naïve cattle via transfer of oropharyngeal fluid.

Jonathan Arzt*, Graham Belsham, Louise Lohse, Anette Bøtner, Carolina Stenfeldt

*Corresponding author for this work

    Research output: Contribution to journalJournal articleResearchpeer-review

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    Abstract

    Control and eradication of foot-and-mouth disease (FMD) is impeded by the existence of a persistent, subclinical, phase of infection in ruminants; animals with this status are referred to as carriers. However, the epidemiological significance of these FMD virus (FMDV) carriers is
    uncertain. In the current investigation, the contagion associated with FMDV carrier cattle was investigated by exposure of susceptible cattle and pigs to oropharyngeal fluid (OPF) or tissues harvested from persistently infected cattle. Naïve cattle were inoculated through intra
    nasopharyngeal deposition of unprocessed OPF that had been collected from FMDV carriers at 30 days post infection. These inoculated cattle developed clinical FMD of similar severity as animals that had been infected with a high-titer inoculum. In contrast, pigs exposed via intra
    oropharyngeal inoculation of the same OPF, or by ingestion of nasopharyngeal tissues harvested from the same cohort of persistently infected cattle, did not develop FMD. These findings indicate that there is demonstrable contagion associated with FMDV carrier cattle despite the
    lack of evidence for transmission by direct contact. The findings presented herein provide novel information that should be considered for FMD risk mitigation strategies.
    Original languageEnglish
    JournalmSphere
    Volume3
    Issue number5
    Number of pages31
    ISSN1535-9786
    DOIs
    Publication statusPublished - 2018

    Bibliographical note

    This is a work of the U.S. Government and is not subject to copyright protection in the United States. Foreign copyrights may apply.

    Keywords

    • FMDV
    • Carrier
    • Cow
    • Foot-and-mouth disease
    • Foot-and-mouth disease virus
    • Risk
    • Transmission
    • Virus

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