Translational Informatics in Toxicology

This thesis, and the subjects presented herein, is a condensed representation of most of the comprehensive scientific projects I have been working on, or been involved in, during my years as a PhD student. The work was mainly carried out at the Techical University of Denmark (DTU) (Danish: Danmarks Tekniske Universitet (DTU)), 2011–2017, under the main supervision of Associate Professor Olivier Taboureau and later by Professor Ole Lund. The project has also been supervised by Professor Søren Brunak and Assistant Professor Karine Audouze.
Entitled ‘Translational Informatics in Toxicology’, the focus of the project–and the subjects covered within this thesis–is primarily on my work on translational informatics, including, but not limited to, data base management, data integration, data analysis, statistics and web services, in relation to toxicology. The work was mainly conducted as a member of the research group Computational Chemical Biology (CCB), at the Department of Bio and Health Informatics (DBHI) (Danish: Institut for Bio- og Sundhedshedsinformatik (IBSI)), at DTU in Kongens Lyngby, Denmark. Additionally, some parts of the work was carried out during my external stay, visiting our partners in the research group CCB led by John Overrington at the European Bioinformatics Institute (EMBL-EBI), the bioinformatics node of the European Molecular Biology Laboratory (EMBL), located at the Wellcome Genome Campus in Hinxton in Cambridgeshire, the United Kingdom.
As a significant amount of time and work, was also put into another project–a small part of the thesis will deal with this work. The project focused on facial appearance, and a great part of this work was conducted by colleagues of mine, where I assisted as a guest member in their research group–Behavial Phenomics–led by Hanne Jarmer, at the DBHI.
The PhD was funded by the Innovative Medicines Initiative Joint Undertaking (IMI-JU), as a part of the eTOX project, and by DTU’s PhD scholarship.