Transketolase from Escherichia coli: a practical procedure for using the biocatalyst for asymmetric carbon-carbon bond synthesis

KG Morris, MEB Smith, NJ Turner, MD Lilly, RK Mitra, John Woodley

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

A practical procedure is reported for the use of the enzyme transketolase, from Escherichia coli, for asymmetric carbon-carbon bond synthesis. The reactions with the biocatalyst are conveniently carried out, on a gram scale, in unbuffered aqueous media by employing a pH autotitrator. An improved large scale synthesis of hydroxypyruvate is also reported.
Original languageEnglish
JournalTetrahedron Asymmetry
Volume7
Pages (from-to)2185-2188
ISSN0957-4166
DOIs
Publication statusPublished - 1996
Externally publishedYes

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